Central neurogenetic signatures of the visuomotor integration system.

Proceedings of the National Academy of Sciences of the United States of America
Elisenda BueichekúJorge Sepulcre

Abstract

Visuomotor impairments characterize numerous neurological disorders and neurogenetic syndromes, such as autism spectrum disorder (ASD) and Dravet, Fragile X, Prader-Willi, Turner, and Williams syndromes. Despite recent advances in systems neuroscience, the biological basis underlying visuomotor functional impairments associated with these clinical conditions is poorly understood. In this study, we used neuroimaging connectomic approaches to map the visuomotor integration (VMI) system in the human brain and investigated the topology approximation of the VMI network to the Allen Human Brain Atlas, a whole-brain transcriptome-wide atlas of cortical genetic expression. We found the genetic expression of four genes-TBR1, SCN1A, MAGEL2, and CACNB4-to be prominently associated with visuomotor integrators in the human cortex. TBR1 gene transcripts, an ASD gene whose expression is related to neural development of the cortex and the hippocampus, showed a central spatial allocation within the VMI system. Our findings delineate gene expression traits underlying the VMI system in the human cortex, where specific genes, such as TBR1, are likely to play a central role in its neuronal organization, as well as on specific phenotypes of neurogen...Continue Reading

References

Mar 1, 1985·Journal of Learning Disabilities·L J Lewandowski
Feb 1, 1980·Perceptual and Motor Skills·S C Fulkerson, W M Freeman
Feb 14, 1998·Neuropsychology·Robert T SchultzDavid Pauls
Feb 27, 2001·Nature Neuroscience·A AmediE Zohary
May 19, 2001·American Journal of Human Genetics·L ClaesP De Jonghe
Oct 30, 2001·Behavioural Brain Research·Y BenjaminiI Golani
May 7, 2002·Neuropsychologia·Thomas W JamesMelvyn A Goodale
Feb 13, 2003·Experimental Brain Research·Burkhard PlegerMartin Tegenthoff
Aug 30, 2003·Neuroscience and Biobehavioral Reviews·Maria W G Nijhuis-van der SandenBarto J Otten
Dec 25, 2003·Vision Research·Gustavo Deco, Edmund T Rolls
Jun 11, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jeremy P YoungPer E Roland
Jun 26, 2004·Annual Review of Neuroscience·Giacomo Rizzolatti, Laila Craighero
Dec 29, 2004·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Joanne Rovet
Nov 8, 2005·Current Opinion in Neurobiology·Giacomo Rizzolatti, Daniel M Wolpert
Dec 2, 2005·Trends in Cognitive Sciences·John T Serences, Steven Yantis
Mar 28, 2006·Current Opinion in Neurobiology·Jody C Culham, Kenneth F Valyear
Apr 29, 2006·American Journal of Medical Genetics. Part a·Mie-Jef DescheemaekerJean-Pierre Fryns
May 30, 2006·Journal of Physiology, Paris·Ulrike Halsband, Regine K Lange
Mar 30, 2007·Journal of Intellectual Disability Research : JIDR·J JauregiD Thuilleaux
Sep 14, 2007·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Susan Dickerson Mayes, Susan L Calhoun
May 30, 2009·Epilepsia·Antonio Gambardella, Carla Marini
Mar 3, 2010·Annual Review of Neuroscience·James W Bisley, Michael E Goldberg
Mar 3, 2010·Journal of Autism and Developmental Disorders·Kimberly A FournierJames H Cauraugh
Mar 11, 2010·Nature Reviews. Neuroscience·Giacomo Rizzolatti, Corrado Sinigaglia
May 7, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Simon B EickhoffTimothy E J Behrens
Jun 30, 2010·The European Journal of Neuroscience·Marcus J NaumerGrit Hein
Jul 27, 2010·Bioinformatics·Christian T LopesGary D Bader
Sep 14, 2010·Epilepsia·Andrew Escayg, Alan L Goldin
Dec 15, 2010·Journal of Neurophysiology·Giovanni GentileH Henrik Ehrsson
Apr 8, 2011·Epilepsia·Charlotte Dravet
Apr 8, 2011·Epilepsia·Carla MariniRenzo Guerrini
Apr 9, 2011·Epilepsy Research·Daniela ChieffoFrancesco Guzzetta
Jul 16, 2011·Epilepsia·Matthias J Koepp
Aug 4, 2011·NeuroImage·Koene R A Van DijkRandy L Buckner
Aug 23, 2011·Journal of Neurodevelopmental Disorders·Elisabeth M DykensElizabeth Roof
Sep 29, 2011·PloS One·Evelin WackerFelix Blankenburg
Nov 25, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shahabeddin VahdatDavid J Ostry
Jun 2, 2012·Neuroscience and Biobehavioral Reviews·Linda ReusMaria W G Nijhuis-van der Sanden

❮ Previous
Next ❯

Citations

Jan 14, 2021·Scientific Reports·Yvan PratvielLaurent M Arsac
Nov 22, 2020·Cells·Marta Garcia-FornSilvia De Rubeis
Mar 2, 2021·Epilepsia·Margherita BertuccelliAlessandra Del Felice
May 7, 2021·Neuropathology and Applied Neurobiology·Antonio Jimenez-MarinJesus M Cortes
Jul 7, 2021·Current Opinion in Neurology·Ibai Diez, Jorge Sepulcre
Aug 13, 2021·Frontiers in Human Neuroscience·William OrwigJorge Sepulcre
Oct 6, 2021·Scientific Reports·Elisenda BueichekúJorge Sepulcre

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

Related Papers

Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence
Ryan R GreenJanet E Lainhart
Exercise and Sport Sciences Reviews
J F Kalaska, T Drew
© 2021 Meta ULC. All rights reserved