PMID: 6112793Jan 1, 1980Paper

Central neurotransmitter mechanisms involved in the control of urinary bladder function. An experimental study in the rat

Scandinavian Journal of Urology and Nephrology. Supplementum
U Sillén

Abstract

Central neurotransmitter systems have been activated in anaesthetized rats, while the effects on the urinary bladder have been recorded by cystometric procedures. Stimulation of central catecholamine neurons with the amine precursor L-3,4-dihydroxyphenylalanine (L-DOPA), after peripheral inhibition of the degradating enzyme dopadecarboxylase, resulted in a hyperactive urinary bladder response. This bladder action seems to be elicited mainly via central dopamine receptors, and mediated via neurons of non-catecholamine type. Activation of central muscarinic receptors with oxotremorine, after pretreatment with methylscopolamine, induced a hyperactive urinary bladder response, which is suggested to originate in pontine-mesencephalic structures as well. There might in some instances be an interaction with muscarinic receptors in the generation of the bladder hyperreactivity to L-DOPA, at the pontine-mesencephalic brain level. The bladder response to stimulation of central muscarinic receptors, on the other hand, seems to be independent of intact adrenergic neurons. The peripheral mediation of the bladder response to L-DOPA is propagated via the pelvic nerves; in the peripheral ganglia via cholinergic receptors, but in the bladder de...Continue Reading

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