PMID: 9535124Apr 16, 1998Paper

Central NO is involved in the antinociceptive action of intracisternal antidepressants in freely moving rats

Neuroscience Letters
D K AhnJ S Park

Abstract

The present study was performed to examine the central effects of antidepressants on nociceptive jaw opening reflex after intracisternal injection. we also investigated the mechanisms of central antinociceptive action of intracisternal antidepressants. We recorded the jaw opening reflex in freely moving rats and chose to administer antidepressants intracisternally in order to eliminate the effects of anesthetic agents on the pain assessment and evaluate the importance of the spinal site of action of antidepressants. After intracisternal injection of 15 microg imipramine, digastric electromyogram (dEMG) was decreased to 76+/-6% of the control. Intracisternal administration of 30 microg desipramine, nortriptyline or imipramine suppressed dEMG remarkably to 48+/-2, 27+/-8, or 25+/-5% of the control, respectively. The suppression of dEMG was maintained for 50 min. L-NG-Nitroarginine methyl ester (NAME) blocked the suppression of dEMG from 32+/-2 to 81+/-5% of the control. These results indicate that antidepressants produce antinociception through central mechanisms in the orofacial area. The central NO pathway seems to be involved in the antinociception of intracisternal antidepressants at supraspinal sites.

References

Jun 17, 1986·European Journal of Pharmacology·M C de FelipeJ A Fuentes
Feb 1, 1993·Pain·S T Meller, G F Gebhart
Aug 1, 1996·Anesthesia and Analgesia·P U RaniJ C Shobha
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Citations

Aug 23, 2002·European Journal of Pharmacology·Daniela Alves, Igor Duarte
Jun 6, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Hyo Sun ChoiDong Kuk Ahn
Jul 3, 1999·Progress in Neuro-psychopharmacology & Biological Psychiatry·D K AhnJ S Park
Oct 31, 2002·The European Journal of Neuroscience·Claudia H TambeliRobert W Gear
Dec 6, 2011·Nitric Oxide : Biology and Chemistry·Wenguo FanHongwen He
Apr 5, 2011·Experimental Neurology·Robert W Gear, Jon D Levine
Feb 26, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Gwi Y YangDong K Ahn
May 22, 2010·European Journal of Pain : EJP·Kunihiro NakaiKoichi Ueda
Jan 22, 2010·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Yuan Gao, Yin-Zhong Duan
Apr 20, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ho Jeong LeeDong Kuk Ahn
Jul 23, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kui Y YangDong K Ahn
Oct 25, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Seung R HanDong K Ahn
Nov 13, 2013·The Journal of Pain : Official Journal of the American Pain Society·Kyoung A WonDong K Ahn

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