Central noradrenergic blockade prevents autotomy in rat: implication for pharmacological prevention of postdenervation pain syndrome

Brain Research Bulletin
Samir Al-AdawiMojtaba Zarei

Abstract

Following transection of peripheral nerve, rats exhibit autotomy, which is considered to be the animal model of postdenervation pain syndrome. It has been suggested that phantom limb pain is a result of peripheral denervation leading to reorganization of somatosensory pathways, particularly in the cerebral cortex, which is shown to depend upon central noradrenergic activity. In this study, sciatic and saphenous nerves were sectioned in the left hindpaw of 30 adult rats resulting in complete loss of pain sensation in the hindpaw. A group of rats received normal saline, compared to another group which received N-(2-) Chloroethyl-N-ethyl-2-bromobenzylamine (DSP4) injection 24 h prior to transection. The latter group was also compared to a third group whose central noradrenergic system were also blocked by bilateral injection of 6-OHDA into the ascending noradrenergic bundle 1 week prior to transection. A fourth group received contralateral cortical ablation in addition to peripheral nerve transection and was compared to the first group whose cortex remained intact. The animals were observed daily for 60 days and autotomy was scored in accordance to the system of Wall et al. After 1 week, control animals began to exhibit autotomy. ...Continue Reading

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Citations

Oct 15, 2009·Experimental Brain Research·Hanna Viisanen, Antti Pertovaara
Jul 15, 2004·Clinical Neuropharmacology·Philip A HannaArthur S Walters
Oct 13, 2006·Progress in Neurobiology·Antti Pertovaara
Jan 18, 2011·Brain Research·Amteshwar Singh Jaggi, Nirmal Singh
Sep 30, 2016·Journal of Neuroscience Research·Bradley K Taylor, Karin N Westlund
Feb 19, 2009·Neuroscience·J J Brightwell, B K Taylor

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