PMID: 3919422Jan 1, 1985Paper

Central noradrenergic neurons and the hypertensive effects of intracerebroventricularly administered prostaglandin E2 in anaesthetized rabbits

Prostaglandins
T OtoriiK Suzuki

Abstract

The participation of central noradrenergic neurons in the pressor responses to intracerebroventricular (i.c.v.) administration of prostaglandin (PG) E2 was studied in anaesthetized rabbits. The hypertensive effect induced by i.c.v. injection of PGE2 was inhibited by i.c.v. pretreatment with 6-hydroxydopamine and phentolamine, but not propranolol. These findings suggest that the cerebral noradrenergic neurons may be involved in the development of hypertensive effect of PGE2 through the adrenergic alpha-receptors.

References

Mar 1, 1976·Prostaglandins·D J Rinchuse, R R Deuben
Mar 1, 1973·European Journal of Pharmacology·S BergströmK Fuxe
Feb 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·E A GyangJ P Buckley
Feb 1, 1973·British Journal of Pharmacology·C T Dollery, J L Reid
Nov 1, 1980·British Journal of Pharmacology·K Hillier, W W Templeton
Jan 28, 1983·European Journal of Pharmacology·E K Chiu, J S Richardson
Jan 14, 1982·Brain Research·G FeuersteinD M Jacobowitz
Dec 1, 1954·The Journal of Comparative Neurology·C H SAWYERJ D GREEN

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