Central NOS inhibition differentially affects vasopressin gene expression in hypothalamic nuclei in septic rats

Journal of Neuroimmunology
Gabriela Ravanelli Oliveira-PelegrinMaria José Alves Rocha

Abstract

Our aim was to investigate the effect of central NOS inhibition on hypothalamic arginine vasopressin (AVP) gene expression, hormone release and on the cardiovascular response during experimental sepsis. Male Wistar rats were intracerebroventricularly injected with the non-selective NO synthase (NOS) inhibitor (L-NAME) or aminoguanidine, a selective inhibitor of the inducible isoform (iNOS). After 30 min, sepsis was induced by cecal ligation and puncture (CLP) causing an increase in heart rate (HR), as well as a reduction in median arterial pressure (MAP) and AVP expression ratio (AVP(R)), mainly in the supraoptic nucleus. AVP plasma levels (AVPp) increased in the early but not in the late phase of sepsis. L-NAME pretreatment increased MAP but did not change HR. It also resulted in an increase in AVPp at all time points, except 24h, when it returned to basal levels. AVP(R), however remained reduced in both nuclei. Aminoguanidine pretreatment resulted in increased MAP in the early phase and higher AVP(R) in the supraoptic, but not in the paraventricular nucleus, while AVPp remained elevated at all time points. We suggest that increased central NO production, mainly inducible NOS-derived, reduces AVP gene expression differentially...Continue Reading

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Dec 17, 2008·Neuroimmunomodulation·Gabriela Ravanelli Oliveira-PelegrinMaria José Alves Rocha

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Citations

Dec 24, 2013·Journal of Neuroimmunology·Gabriela R Oliveira-PelegrinMaria José A Rocha
Jul 18, 2015·Molecular Neurobiology·Fazal WahabMaria Jose A Rocha
Mar 26, 2013·Journal of Neuroimmunology·Gabriela Ravanelli Oliveira-PelegrinMaria José Alves Rocha
Sep 16, 2016·Molecular Neurobiology·Luis Henrique Angenendt da CostaMaria José Alves da Rocha
Jan 17, 2017·Pituitary·Camila Henriques CoelhoMaria José Alves da Rocha
Jun 8, 2017·Pituitary·Nilton Nascimento Santos-JuniorMaria José Alves Rocha
Jan 9, 2021·Molecular Neurobiology·Luis Henrique Angenendt da CostaMaria José Alves Rocha

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