Central obesity is associated with non-cirrhotic portal vein thrombosis

Journal of Hepatology
Christophe BureauJean Pierre Vinel

Abstract

30-40% of portal vein thrombosis (PVT) remains of unknown origin. An association between metabolic syndrome (MetS) and peripheral vein thrombosis has been reported but not with PVT, to date. The aim of this study was to investigate the association between MetS and PVT. Between 2003 and 2014, all consecutive patients with non-cirrhotic PVT were prospectively included. Patient's characteristics and risks factors were recorded at the time of inclusion. Controls were selected by random in the general population and were matched 1/1 according to age and sex. Seventy-nine patients with PVT were included: 40 present with at least one risk factor for PVT (SPVT) and 39 were found to be idiopathic (IPVT). The prevalence of MetS was 25.6% in SPVT group vs. 47.4% in IPVT group and 17.9% in controls from the general population (C-IPVT: p=0.01). The waist circumference and body mass index were higher in the IPVT group than in the SPVT group (105 vs. 93cm, p=0.004 and 29.4 vs. 25.0kg/m(2), p=0.004) and in the C-IPVT group (105 vs. 92cm, p=0.001 and 29.4 vs. 25.8kg/m(2), p=0.003). Overweight was observed in 82.0% of patients in the IPVT group vs. 44% in the SPVT group (p=0.002) and 51% in the C-IPVT group (p=0.01). The mean visceral fat area w...Continue Reading

References

Feb 26, 1997·JAMA : the Journal of the American Medical Association·S Z GoldhaberC H Hennekens
Feb 9, 2000·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·J P Bastard, L Piéroni
Mar 8, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M H DenningerD Valla
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Jan 5, 2002·The New England Journal of Medicine·S KumarP S Kamath
Dec 11, 2002·Journal of Gastroenterology and Hepatology·Dominique-Charles VallaDidier Lebrec
Jan 22, 2005·American Heart Journal·Phillippa J MirandaJohn R Guyton
Sep 17, 2005·The American Journal of Medicine·Paul D SteinRonald E Olson
Mar 7, 2007·Haematologica·Cihan AyIngrid Pabinger
Aug 19, 2007·BMC Gastroenterology·Kirstine K SogaardHenning Gronbaek
Nov 6, 2007·Diabetes & Metabolism·B BalkauG Slama
Dec 19, 2007·Circulation·Walter AgenoPieter W Kamphuisen
Jan 30, 2009·Journal of Thrombosis and Haemostasis : JTH·L M SteffenA R Folsom
Apr 29, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Laurie D DeLeveUNKNOWN American Association for the Study Liver Diseases
May 12, 2009·Archives of Cardiovascular Diseases·Jean FerrièresJean-Bernard Ruidavets
Oct 13, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Aurelie PlessierUNKNOWN European Network for Vascular Disorders of the Liver (EN-Vie)
Oct 17, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Knut H BorchJohn-Bjarne Hansen
Oct 28, 2009·Circulation·Marianne Tang SeverinsenKim Overvad
Dec 8, 2009·Blood·Jildou HoekstraUNKNOWN European Network for Vascular Disorders of the Liver (EN-Vie)
Oct 1, 2010·The New England Journal of Medicine·Giovanni TargherEnzo Bonora
Dec 8, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Anna KotronenHannele Yki-Järvinen
Aug 23, 2012·BMC Gastroenterology·Rosa AyalaJoaquín Martínez-López
May 22, 2013·Current Pharmaceutical Design·Katrin Schäfer, Stavros Konstantinides
Aug 28, 2013·Journal of Hepatology·Rajeev Khanna, Shiv K Sarin
Nov 19, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Laure ElkriefAurélie Plessier
Mar 25, 2014·Journal of Hepatology·Armando TripodiSilvia Fargion
Sep 1, 2014·Journal of Hepatology·Fanny TuronJuan Carlos Garcia-Pagán

❮ Previous
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Citations

Apr 22, 2017·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Khaled M ElsayesChristine O Menias
Mar 23, 2017·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Kwang Il SeoJung Gu Park
Aug 18, 2017·Internal and Emergency Medicine·Clara Benedetta ContiDario Conte
Oct 7, 2017·Abdominal Radiology·Susana G RodriguesAnnalisa Berzigotti
Aug 10, 2018·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Uchenna AgbimSanjaya K Satapathy
Aug 9, 2019·Expert Review of Gastroenterology & Hepatology·Marta Hernández-CondeJosé Luis Calleja
May 29, 2018·Asian Journal of Endoscopic Surgery·Manabu AmikiYoshimochi Kurokawa
Apr 26, 2019·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Lorena ReyesJosé Antonio Páramo
Nov 22, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Patrick G NorthupDominique C Valla
Dec 30, 2020·BMJ Case Reports·Omkaar JaikaranVadim Meytes
Jul 25, 2021·Clinics and Research in Hepatology and Gastroenterology·Tatiana Stempak-DroissartAnne Gompel

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