Central oxytocin attenuates augmented gastric postprandial motility induced by restraint stress in rats

Neuroscience Letters
Mehmet BülbülToku Takahashi

Abstract

Restraint stress delays gastric emptying via uncoordinated motility pattern in rats. Central oxytocin has anxiolytic effects and attenuates the hypothalamic-pituitary-adrenal (HPA) axis in response to stress and facilitates stress-induced delayed gastric emptying. However, the role of central oxytocin in regulating gastric motility remains unknown. Postprandial gastric motility was recorded via a strain-gauge transducer, implanted on the antrum in Sprague-Dawley (SD) rats. To investigate whether central and peripheral oxytocin are involved in gastric motility, oxytocin (10 microg) was administered intracerebroventricularly (icv) and intraperitoneally (ip). Central and peripheral oxytocin administration did not affect the postprandial gastric motility under non-stressed conditions. Restraint stress augmented gastric contractions. Central administration of oxytocin, but not peripheral administration, abolished the augmented postprandial gastric contractions induced by restraint stress. Oxytocin facilitates stress-induced delayed gastric emptying via alleviating uncoordinated gastric motility. Oxytocin might be a candidate for the treatment of stress-induced GI motility disorders.

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Citations

Dec 21, 2013·Biochemical Pharmacology·Tanja Babic, R Alberto Travagli
Apr 17, 2013·The Journal of Physiology·Gregory M HolmesR Alberto Travagli
Sep 27, 2015·Frontiers in Neuroendocrinology·Amanda E Elson, Richard B Simerly
Dec 23, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·I J Llewellyn-SmithR Alberto Travagli
Mar 9, 2011·Brain Research·Mehmet BülbülToku Takahashi
Jan 17, 2012·Autonomic Neuroscience : Basic & Clinical·Reji BabygirijaToku Takahashi
Jun 3, 2016·Nature Reviews. Gastroenterology & Hepatology·R Alberto Travagli, Laura Anselmi
Nov 13, 2018·Current Opinion in Endocrinology, Diabetes, and Obesity·Kirsteen N Browning, R Alberto Travagli
Jan 14, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mehmet BülbülToku Takahashi
Oct 8, 2019·Journal of Neurogastroenterology and Motility·Yu YangJun Zheng
Jun 27, 2019·Current Obesity Reports·Cherlyn Ding, Faidon Magkos
Sep 23, 2011·Stress : the International Journal on the Biology of Stress·Sazu YoshimotoToku Takahashi

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