Central oxytocin modulation of acute stress-induced cardiovascular responses after myocardial infarction in the rat

Stress : the International Journal on the Biology of Stress
Agnieszka WsółJakub Dobruch

Abstract

The present study was aimed at determining the role of centrally released oxytocin in regulation of blood pressure and heart rate (HR) under resting conditions and during an acute air-jet stress in rats with a myocardial infarction and controls infarcted. Four weeks after ligation of a coronary artery or sham surgery, conscious Sprague Dawley rats were subjected to one of the following intracerebroventricular (ICV) infusions: (1) 0.9% NaCl (control), (2) oxytocin, (3) oxytocin receptor antagonist {desGly-NH(2)-d(CH(2))(5)[D-Tyr(2)Thr(4)]OVT}(OXYANT). Resting arterial blood pressure and HR were not affected by any of the ICV infusions either in the infarcted or sham-operated rats. In the control experiments, the pressor and tachycardic responses to the air jet of infarcted rats were significantly greater than in the sham-operated rats. OXYANT significantly enhanced the cardiovascular responses to stress only in the sham-operated rats whereas oxytocin significantly attenuated both responses in the infarcted but not in the sham-operated rats. The results suggest that centrally released endogenous oxytocin significantly reduces the cardiovascular responses to the acute stressor in control rats. This buffering function of the brain-...Continue Reading

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Citations

Mar 30, 2016·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Jolanta GutkowskaTom L Broderick
Feb 19, 2014·Physiology & Behavior·William M KenkelC Sue Carter
Dec 7, 2013·Stress : the International Journal on the Biology of Stress·A WsolA Cudnoch-Jedrzejewska
Nov 27, 2014·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·E QuagliottoA A Rasia-Filho
Feb 15, 2020·American Journal of Physiology. Heart and Circulatory Physiology·E Szczepanska-SadowskaA Wsol
Dec 14, 2016·BioMed Research International·Agnieszka WsolAgnieszka Cudnoch-Jedrzejewska
Oct 24, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Agnieszka WsolAgnieszka Cudnoch-Jedrzejewska
Oct 21, 2017·Heart Failure Reviews·Antonios RigasJohn Parissis
Jan 30, 2021·Life Sciences·Stephani C Wang, Yu-Feng Wang

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