Central pathways of pulmonary and lower airway vagal afferents.

Journal of Applied Physiology
Leszek KubinDonald R McCrimmon

Abstract

Lung sensory receptors with afferent fibers coursing in the vagus nerves are broadly divided into three groups: slowly (SAR) and rapidly (RAR) adapting stretch receptors and bronchopulmonary C fibers. Central terminations of each group are found in largely nonoverlapping regions of the caudal half of the nucleus of the solitary tract (NTS). Second order neurons in the pathways from these receptors innervate neurons located in respiratory-related regions of the medulla, pons, and spinal cord. The relative ease of selective activation of SARs, and to a lesser extent RARs, has allowed for more complete physiological and morphological characterization of the second and higher order neurons in these pathways than for C fibers. A subset of NTS neurons receiving afferent input from SARs (termed pump or P-cells) mediates the Breuer-Hering reflex and inhibits neurons receiving afferent input from RARs. P-cells and second order neurons in the RAR pathway also provide inputs to regions of the ventrolateral medulla involved in control of respiratory motor pattern, i.e., regions containing a predominance of bulbospinal premotor neurons, as well as regions containing respiratory rhythm-generating neurons. Axon collaterals from both P-cells a...Continue Reading

References

Apr 1, 1992·Journal of Applied Physiology·K G HenkeJ A Dempsey
Jan 1, 1992·Physiological Reviews·B L Jacobs, E C Azmitia
Jul 1, 1990·Pflügers Archiv : European journal of physiology·G S Mitchell
Aug 22, 1988·The Journal of Comparative Neurology·M Kalia, D Richter
Feb 1, 1989·The American Journal of Physiology·J BajićF A Hopp
Jan 1, 1989·Physiological Reviews·D Bartlett
Jan 1, 1989·Pharmacology & Therapeutics·H M ColeridgeH D Schultz
Dec 1, 1987·Journal of Applied Physiology·W M St John
Dec 1, 1987·The American Journal of Physiology·E J Zuperku, F A Hopp
Apr 1, 1987·Journal of Applied Physiology·L Kubin, R O Davies
Jun 3, 1985·Brain Research·J Y Wei, E Shen
Jun 1, 1985·Journal of the Autonomic Nervous System·J Perrin, J Crousillat
Jul 1, 1974·Respiration Physiology·G Miserocchi, G Sant'Ambrogio
Apr 1, 1972·The Journal of Physiology·F J Clark, C von Euler
Dec 1, 1980·Journal of Neuroscience Methods·G PaxinosP C Emson

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Citations

Aug 16, 2008·Pflügers Archiv : European journal of physiology·Armenak BantikyanChi-Sang Poon
Feb 19, 2013·Pflügers Archiv : European journal of physiology·Tomohiro NumataYasuo Mori
Oct 15, 2013·Respiratory Physiology & Neurobiology·Michael W CalikDavid W Carley
Aug 30, 2011·Nature Chemical Biology·Nobuaki TakahashiYasuo Mori
Jun 29, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Brendan J Canning, Nanako Mori
Aug 5, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Michael Mörschel, Mathias Dutschmann
Aug 5, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M DutschmannJ F R Paton
Aug 24, 2007·Clinical and Experimental Pharmacology & Physiology·Stuart B Mazzone, Alice E McGovern
Sep 16, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Michael C Andresen, James H Peters
Mar 10, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·T Luise KingEileen M Hasser
Aug 14, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Keith B HengenStephen M Johnson
Oct 19, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael C AndresenJessica A Fawley
Jan 16, 2010·Journal of Applied Physiology·Patrice G GuyenetRoy Kanbar
Nov 2, 2012·Journal of Neurophysiology·Stuart J McDougall, Michael C Andresen
Jul 18, 2008·Journal of Neurophysiology·Lauren S SegersBruce G Lindsey
Jul 14, 2010·American Journal of Respiratory and Critical Care Medicine·Roy KanbarPatrice G Guyenet
Nov 15, 2011·Cough·Stuart M Brooks
May 17, 2011·Critical Care : the Official Journal of the Critical Care Forum·María Elisa QuilezJosefina López-Aguilar
Dec 10, 2013·Critical Care : the Official Journal of the Critical Care Forum·Eline OppersmaLeo M A Heunks
Feb 5, 2009·Pediatric Research·Amitai Z KohnPrabha Kc
Feb 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stephen B G AbbottPatrice G Guyenet
Mar 29, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wiktor A JanczewskiJack L Feldman
Oct 16, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stuart J McDougallMichael C Andresen
Feb 26, 2014·Respiratory Physiology & Neurobiology·Mathias DutschmannThomas E Dick
Nov 5, 2013·European Journal of Pharmacology·Tanja Babic, Kirsteen N Browning
Jan 9, 2014·Physiological Reports·Elenia CinelliDonatella Mutolo
Oct 29, 2013·Antioxidants & Redox Signaling·Daisuke KozaiYasuo Mori
Oct 26, 2014·Journal of Surgical Case Reports·Stephen P Williams, Mahmood F Bhutta
Sep 15, 2014·Respiratory Physiology & Neurobiology·Eduardo V Lemes, Daniel B Zoccal
Apr 30, 2014·Pflügers Archiv : European journal of physiology·Rosélia S DamascenoThiago S Moreira
Apr 25, 2013·American Journal of Physiology. Endocrinology and Metabolism·Keegan T MurphyTimothy J Bartness
Jul 20, 2011·Journal of Medical Engineering & Technology·Matevz LeskovsekMatjaz Bunc
Feb 3, 2016·Brain Research·John Ciriello, Monica M Caverson
May 24, 2014·Expert Review of Neurotherapeutics·Adrián González-LópezKonrad Talbot
Feb 5, 2014·The Journal of Physiology·Elenia CinelliFulvia Bongianni

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