PMID: 25917480Apr 29, 2015Paper

Central pontine myelinolysis: a rare presentation secondary to hyperglycaemia

Singapore Medical Journal
Monica SainiRajinder Singh

Abstract

Central pontine myelinolysis (CPM) is classically described as a demyelinating condition that results from the rapid correction of hyponatraemia. CPM has also been reported to arise from hyperglycaemia in association with concomitant acidosis, hypernatraemia and hyperosmolar syndrome. Herein, we report a rare presentation of CPM, which was purely secondary to hyperosmolar hyperglycaemia. The patient presented with ataxia and pseudobulbar affect, which evolved subacutely over a duration of two weeks. It is important to note that, in addition to acute changes in osmolality, a subacute shift secondary to hyperglycaemia may also lead to CPM.

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Citations

Sep 20, 2017·Endocrinology, Diabetes & Metabolism Case Reports·Swapna TalluriKerri Kissell
Nov 3, 2017·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Peter Bede, Eoin Finegan
Apr 11, 2020·Case Reports in Nephrology·Carolina OrmondeSara Serpa
Aug 10, 2018·Indian Journal of Endocrinology and Metabolism·Kiran Kumar RamineniRavi Kanth Jakkani
Dec 10, 2020·Clinical Diabetes and Endocrinology·Koshi KusumotoYoshihiko Nishio
Jul 6, 2021·World Journal of Clinical Cases·Xiao-Yong ShiJin-Xia Zhang

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