Central pontine myelinolysis in a patient with acute lymphoblastic leukemia after hematopoietic stem cell transplantation: a case report.

Journal of Korean Medical Science
Kyu-Hyoung LimByoung Kook Kim

Abstract

We describe a 37-yr-old man who developed central pontine myelinolysis (CPM) after allogeneic hematopoietic stem cell transplantation (HSCT) for acute lymphoblastic leukemia. After HSCT, desquamation developed on the whole body accompanied by hyperbilirubinemia. The liver biopsy of the patient indicated graft-versus-host disease- related liver disease, and the dose of methylprednisolone was increased. Then, the patient developed altered mentality with eye ball deviation to the left, for which electroencephalogram and magnetic resonance imaging (MRI) scans were done. Brain MRI scan demonstrated the imaging findings consistent with central pontine myelinolysis and extrapontine myelinolysis. He did not have any hyponatremia episode during hospitalization prior to the MRI scan. To the best of our knowledge, presentation of CPM after allogeneic HSCT is extremely rare in cases where patients have not exhibited any episodes of significant hyponatremia. We report a rare case in which hepatic dysfunction due to graft-versus-host disease has a strong association with CPM after HSCT.

References

Feb 1, 1994·Journal of the American Society of Nephrology : JASN·R H SternsE P Cohen
Jun 30, 2001·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·H Ashrafian, P Davey
Jan 23, 2002·European Neurology·Christian Lampl, Kambiz Yazdi

❮ Previous
Next ❯

Citations

Aug 17, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Hulya AslanHuseyin G Tore
Feb 8, 2013·Journal of Child Neurology·Preeti SharmaSatinder Aneja
Jun 1, 2012·Journal of Child Neurology·Adrianna M RangerDouglas Fraser
Jul 12, 2018·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Mara BonardiFederico Zappoli Thyrion

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Related Papers

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Carlijn I Buis, Eelco F M Wijdicks
Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Bart PostM A J Tijssen
© 2022 Meta ULC. All rights reserved