Central pontine myelinolysis in the hyperosmolar hyperglycaemic state.

Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre
Mohamed Osama Hegazi, Anant Mashankar

Abstract

To report a rare association of central pontine myelinolysis (CPM) with hyperosmolar hyperglycaemic state (HHS). A diabetic female presented with HHS and prolonged severe hypernatraemia. The metabolic derangement was adequately treated with proper correction of both hyperglycaemia and hypernatraemia. Lack of improvement in the presenting confusional state and the development of a fresh neurological deterioration led to the suspicion of CPM that was confirmed with magnetic resonance imaging. She fully recovered after 4 weeks with no specific medical treatment. This case report showed that osmotic demyelination was linked to hypernatraemia and that CPM could result from severe hypernatraemia of HHS.

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Citations

Dec 3, 2014·Neurología : publicación oficial de la Sociedad Española de Neurología·J A Matías-GuiuM Ruiz-Yagüe
Nov 10, 2013·The Journal of Emergency Medicine·Azeemuddin AhmedAmy Engelman
Apr 29, 2015·Singapore Medical Journal·Monica SainiRajinder Singh
Oct 18, 2014·World Journal of Clinical Cases·George LiamisMoses Elisaf
May 31, 2017·Neurology·Jorge Risco, Menachem Weiss
Aug 10, 2018·Indian Journal of Endocrinology and Metabolism·Kiran Kumar RamineniRavi Kanth Jakkani
Dec 10, 2020·Clinical Diabetes and Endocrinology·Koshi KusumotoYoshihiko Nishio
Jun 29, 2021·International Medical Case Reports Journal·Shoko NiidaIchiro Takeuchi

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