Central processing of tactile and nociceptive stimuli in complex regional pain syndrome

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Nuutti V VartiainenNina Forss

Abstract

Patients with complex regional pain syndrome (CRPS) suffer from continuous regional limb pain and from hyperesthesia to touch and pain. To better understand the pathophysiological mechanisms underlying the hyperesthesia of CRPS patients, we investigated their cortical processing of touch and acute pain. Cortical responses to tactile stimuli applied to the thumbs, index and little fingers (D1, D2, and D5) and nociceptive stimuli delivered to dorsa of the hands were recorded with a whole-scalp neuromagnetometer from eight chronic CRPS patients and from nine healthy control subjects. In the patients, primary somatosensory (SI) cortex activation to tactile stimulation of D2 was significantly stronger, and the D1-D5 distance in SI was significantly smaller for the painful hand compared to the healthy hand. The PPC activation to tactile stimulation was significantly weaker in the patients than in the control subjects. To nociceptive stimulation with equal laser energy, the secondary somatosensory (SII) cortices and posterior parietal cortex (PPC) were similarly activated in both groups. The PPC source strength correlated with the pain rating in the control subjects, but not in the patients. The enhanced SI activation in hyperesthetic...Continue Reading

References

Aug 1, 1991·Brain : a Journal of Neurology·R D TreedeB Bromm
Oct 1, 1995·Pain·M Stanton-HicksP Wilson
Jul 1, 1996·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·H C HansenB Bromm
Jan 14, 1998·Neuroreport·L García-LarreaF Mauguière
Jul 25, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·M Mertens, B Lütkenhöner
Dec 29, 2000·Neurophysiologie clinique = Clinical neurophysiology·R PeyronL García-Larrea
Nov 14, 2002·Brain : a Journal of Neurology·Luis Garcia-LarreaFrançois Mauguière
Apr 10, 2003·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Tuukka T RaijRiitta Hari
Apr 11, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·A TruiniG Cruccu
Oct 24, 2003·Lancet Neurology·Wilfrid Jänig, Ralf Baron
Dec 18, 2003·Neurophysiologie clinique = Clinical neurophysiology·L Garcia-LarreaM Valeriani
Dec 18, 2003·Neurophysiologie clinique = Clinical neurophysiology·Rolf-Detlef TreedeUlf Baumgärtner
Dec 25, 2003·Neurology·Christian MaihöfnerFrank Birklein
Mar 11, 2004·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G CruccuT S Jensen
Aug 25, 2004·Neurology·Christian MaihöfnerFrank Birklein
Dec 14, 2004·NeuroImage·Nina ForssRiitta Hari
May 6, 2005·Neurology·Nina ForssMaarit Gockel
Feb 7, 2006·NeuroImage·Wei-Ta ChenYung-Yang Lin
Nov 18, 2006·Cerebral Cortex·Maria L StavrinouPaolo Maria Rossini
Jul 1, 1996·Electroencephalography and Clinical Neurophysiology·M ValerianiF Mauguière

❮ Previous
Next ❯

Citations

Oct 12, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Jacqueline BaileyCandida S McCabe
May 1, 2011·Pain Management·Robin Bekrater-BodmannHerta Flor
Dec 3, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Shahab JamaliBernhard Ross
Feb 10, 2016·Frontiers in Human Neuroscience·Anoop KuttikatChristopher Andrew Brown
Oct 29, 2013·Autoimmunity Reviews·A T Borchers, M E Gershwin
Jun 4, 2013·The Journal of Pain : Official Journal of the American Pain Society·Flavia Di PietroTasha R Stanton
Dec 24, 2011·PM & R : the Journal of Injury, Function, and Rehabilitation·Douglas E HenryWeibin Yang
Jun 28, 2011·The Journal of Pain : Official Journal of the American Pain Society·Lone KnudsenPeter D Drummond
Aug 3, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Kristina RoihaNina Forss
May 14, 2010·The Journal of Pain : Official Journal of the American Pain Society·Mary Beth NebelGregory Essick
Feb 27, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Erika KirveskariNina Forss
Nov 28, 2015·Hand Clinics·Maral Tajerian, John David Clark
Sep 27, 2014·Human Brain Mapping·Flavia Di PietroJames H McAuley
Jul 2, 2014·The Journal of Pain : Official Journal of the American Pain Society·Mark J CatleyG Lorimer Moseley
Dec 20, 2014·European Journal of Pain : EJP·E KirveskariN Forss
Oct 17, 2014·European Journal of Pain : EJP·L F Knudsen, P D Drummond
Jul 30, 2009·The Journal of Pain : Official Journal of the American Pain Society·Nuutti VartiainenNina Forss
Sep 9, 2016·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Matthias MichalFrank Birklein
Jan 16, 2015·The Korean Journal of Pain·Won Hyung Lee
Feb 20, 2019·Regional Anesthesia and Pain Medicine·Michael d'A Stanton-Hicks
Aug 1, 2019·Molecular Diagnosis & Therapy·Krishna D BharwaniFrank J P M Huygen
Mar 7, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Dario RicciardiGiovanni Cirillo
May 14, 2020·Behavioural Neurology·Monika HalickaJanet H Bultitude
Sep 25, 2020·Behavioural Brain Research·Janet H Bultitude, Karin Petrini

❮ Previous
Next ❯

Related Concepts

Related Feeds

ALS: Transposon de-silencing

Transposon silencing is a form of transcriptional gene silencing. These gene silencing mechanisms are impaired in Amyotrophic lateral sclerosis (ALS). Here are the latest discoveries pertaining to transposon silencing and this disease.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.