Central regions of keloids are severely ischaemic

Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS
Ryoma TouchiMotomu Tsuji

Abstract

We classified scars as keloids, hypertrophic scars and mature scars, and then examined the scars for differences in central and marginal vascularization. We found significant differences in localized hypoxia-induced factor-1α (HIF-1α) expression and vascular density in keloids, but no localized differences in hypertrophic or mature scars. The central areas of keloids exhibited higher HIF-1α expression and lower vascular density than marginal areas, suggesting that the former are severely ischaemic.

References

Feb 1, 1979·Journal of Cellular Physiology·R F DiegelmannB J McCoy
Oct 1, 1971·Proceedings of the Society for Experimental Biology and Medicine·M R ShetlarD L Larson
Feb 1, 1971·Plastic and Reconstructive Surgery·J E HoopesM J Im
Nov 21, 1998·Human Pathology·T W BeerD H Wright
May 26, 1999·Annals of Plastic Surgery·D S SteinbrechM T Longaker
Aug 24, 1999·Plastic and Reconstructive Surgery·K UedaS Tajima
Aug 23, 2001·Trends in Molecular Medicine·G L Semenza
Oct 22, 2002·American Journal of Physiology. Cell Physiology·Jie ZhouBernhard Brüne
Oct 3, 2003·Pathology, Research and Practice·Thaís AmadeuAndréa Costa
Jan 8, 2004·The Journal of Investigative Dermatology·Qunzhou ZhangAnh D Le
May 22, 2004·Journal of the American Academy of Dermatology·Amy Kim GiraJack L Arbiser
Sep 15, 2004·The American Journal of Dermatopathology·Julia Yu-Yun LeeTak-Wah Wong
Oct 30, 2004·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·Koichi UedaSosuke Oba
Jan 19, 2005·Cell Cycle·Jörn KarhausenSean P Colgan
Feb 3, 2005·International Immunopharmacology·John J Haddad, Hisham L Harb
Oct 19, 2007·The Journal of Investigative Dermatology·Annette S VincentKim P Wong
Jan 25, 2008·Annals of Plastic Surgery·Shigeru IchiokaTakashi Nakatsuka

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Citations

Jun 13, 2020·Frontiers in Cell and Developmental Biology·Grace C LimandjajaSusan Gibbs
Mar 3, 2021·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Yuting YangHong Yan

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