Central respiratory modulation of barosensitive neurones in rat caudal ventrolateral medulla

The Journal of Physiology
Daniel A Mandel, Ann M Schreihofer

Abstract

The sympathetic nerves that maintain blood pressure are modulated by the central respiratory generator. Neurones in the rostral ventrolateral medulla (RVLM) that drive this sympathetic nerve activity (SNA) also display central respiratory drive (CRD)-related activity, suggesting integration of respiratory and cardiovascular regulatory systems within the brainstem. Whether CRD-related activity in the RVLM is due to direct inputs from central respiratory neurones or modulation of cardiovascular-related neurones that influence the RVLM is not known. The caudal ventrolateral medulla (CVLM) contains GABAergic neurones that tonically inhibit presympathetic RVLM neurones and are essential for the production of numerous cardiovascular reflexes. The present study sought to determine whether cardiovascular-related GABAergic neurones in the CVLM display CRD-related activity. The firing patterns of individual barosensitive CVLM neurones were examined in relation to phrenic nerve activity in chloralose-anaesthetized, ventilated, neuromuscularly blocked, vagotomized rats. Histograms of phrenic-triggered CVLM neuronal activity showed that all baro-activated CVLM neurones displayed one of four patterns of CRD-related activity: (i) inspiratory ...Continue Reading

References

Dec 1, 1992·The American Journal of Physiology·A J Verberne, P G Guyenet
Jul 1, 1991·Neuron·M G ErlanderA J Tobin
Nov 1, 1990·The American Journal of Physiology·P G GuyenetT A Riley
Apr 1, 1988·The American Journal of Physiology·W W Blessing
Mar 1, 1989·The American Journal of Physiology·J R Haselton, P G Guyenet
Oct 1, 1985·The American Journal of Physiology·C A Connelly, R D Wurster
Apr 1, 1970·The American Journal of Physiology·M I Cohen, P M Gootman
Jul 1, 1967·The American Journal of Physiology·H Okada, I J Fox
Nov 11, 1982·Pflügers Archiv : European journal of physiology·D JordanK M Spyer
May 17, 1995·Journal of the Autonomic Nervous System·N Koshiya, P G Guyenet
Apr 1, 1995·The American Journal of Physiology·T MiyawakiJ Chalmers
Aug 1, 1994·Progress in Neurobiology·H J HäblerM Michaelis
Jan 1, 1993·The American Journal of Physiology·I JeskeD J Reis
Sep 1, 1995·Clinical and Experimental Pharmacology & Physiology·P Pilowsky
Nov 1, 1996·The American Journal of Physiology·T MiyawakiP Pilowsky
Dec 31, 1997·The Journal of Comparative Neurology·A M Schreihofer, P G Guyenet
Sep 2, 1998·Progress in Neurobiology·S C Malpas
May 11, 1999·The Journal of Comparative Neurology·A M SchreihoferP G Guyenet
Aug 12, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A M Schreihofer, P G Guyenet
Oct 26, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A M Schreihofer, P G Guyenet
May 16, 2002·Clinical and Experimental Pharmacology & Physiology·Ann M Schreihofer, Patrice G Guyenet
Oct 22, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·N RenteroR M McAllen
Mar 4, 2003·Journal of Neurophysiology·Ann M Schreihofer, Patrice G Guyenet
Mar 11, 2003·The Journal of Physiology·Dwain L Eckberg
Mar 6, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Thomas E DickNanduri Prabhakar

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Citations

Mar 30, 2011·Current Hypertension Reports·Daniel B Zoccal, Benedito H Machado
Aug 5, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Paul M PilowskySimon McMullan
May 6, 2009·Clinical and Experimental Pharmacology & Physiology·Daniel B ZoccalBenedito H Machado
Sep 2, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Daniel A Mandel, Ann M Schreihofer
Jan 16, 2010·Journal of Applied Physiology·Patrice G GuyenetRoy Kanbar
Oct 1, 2014·Respiratory Physiology & Neurobiology·Thomas E DickErica A Wehrwein
Dec 3, 2008·The Journal of Physiology·Daniel A Mandel, Ann M Schreihofer
Mar 10, 2010·The Journal of Physiology·Domitila A Huber, Ann M Schreihofer
Aug 12, 2006·The Journal of Physiology·Thiago S MoreiraPatrice G Guyenet
Sep 15, 2010·Respiratory Physiology & Neurobiology·David M BaekeyThomas E Dick
Aug 26, 2010·Respiratory Physiology & Neurobiology·Daniel B Zoccal, Benedito H Machado
Aug 3, 2010·Respiratory Physiology & Neurobiology·A E SimmsA E Pickering
Aug 1, 2009·Respiratory Physiology & Neurobiology·Thomas E DickKendall F Morris
Dec 2, 2006·Experimental Physiology·Thomas E DickNanduri Prabhakar
Jan 5, 2011·Respiratory Physiology & Neurobiology·Irina TopchiyDavid W Carley
Mar 19, 2013·Autonomic Neuroscience : Basic & Clinical·Alfredo J GarciaJan-Marino Ramirez
Jan 12, 2013·Autonomic Neuroscience : Basic & Clinical·Christopher S FreetXiaorui Tang
Jul 11, 2014·Frontiers in Physiology·Daniel B ZoccalEduardo Colombari
Nov 2, 2016·Experimental Physiology·George Miguel P R SouzaBenedito H Machado
Dec 23, 2016·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Yaroslav I MolkovJeffrey C Smith
Jan 23, 2018·Current Hypertension Reports·Mateus R AmorimBenedito H Machado
Aug 14, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S S PanteleevO A Lyubashina
Sep 7, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Daniel B ZoccalAna C Takakura
Sep 7, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Roy KanbarClaude Julien
Jan 17, 2009·The Journal of Physiology·Paul M Pilowsky
Aug 21, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Carol A Everson, Aniko Szabo
Jun 6, 2019·Journal of Neurophysiology·Amelia H GagliusoGay R Holstein

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