Central retinal vein and branch artery occlusion associated with inherited plasminogen deficiency and high lipoprotein(a) levels: a case report

Thrombosis Research
A TavolaA D'Angelo

Abstract

We describe a case of central retinal vein and branch artery occlusion associated with inherited type I plasminogen deficiency (68%) and permanent elevation of Lp(a) (460 mg/l, S2 phenotype) in a 45 year old white woman with no associated local or systemic risk factors. Pedigree analysis revealed inheritance of plasminogen deficiency from the deceased father and of high Lp(a) levels from the mother. Both the patient's sons had plasminogen deficiency, but they had normal Lp(a) levels. In a series of 40 consecutive patients with central retinal vein occlusion we previously reported the observation of high Lp(a) levels--consistently associated with the S2 phenotype--in 30% of the patients as compared to a 10% incidence in controls. This case emphasizes the importance of screening patients with occlusion of the retinal vessels and no associated risk factors for coagulation abnormalities predisposing to thrombosis.

References

Jan 1, 1982·Haemostasis·D MariP M Mannucci

❮ Previous
Next ❯

Citations

Sep 4, 1998·American Journal of Ophthalmology·H IijimaS Tsukahara
Mar 25, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·G Lippi, G Guidi
Jun 14, 2006·Retina·David S ZumbroMichael L Klein
Aug 21, 2013·European Journal of Medical Research·Dieter Schmidt
May 22, 1998·Clinical Chemistry and Laboratory Medicine : CCLM·G Lippi, G Guidi
May 8, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Tatjana StojakovicOtto Schmut
Aug 23, 2016·Acta Ophthalmologica·Claudia Kuhli-HattenbachLars-Olof Hattenbach
Mar 12, 2004·American Journal of Ophthalmology·Claudia KuhliLars-Olof Hattenbach
May 3, 2007·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Rossella MarcucciDomenico Prisco
Jun 5, 2021·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Neha Goel

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.