Central role of supporting cells in cochlear homeostasis and pathology

Medical Hypotheses
R Ramírez-CamachoR Sanz

Abstract

Supporting cells have a crucial role in degenerative and regenerative events of primary sensorial hair cells of the organ of Corti. This new role should determine future studies about pathophysiology of hearing loss and its regenerative treatment. Recent findings suggest an active role of supporting cells in the maintenance of hair cell function and structure. Evidences of high energy consumption and close proximity to auditory nervous fibers suggesting K+ active exchange, preferential expression of specific proteins and antigens, presence of glucocorticoids receptors, affinity for cisplatin and regenerative potential give the supporting cells an important role in homeostasis of the organ of Corti and in some specific diseases affecting this structure. As well as glial cells provide protection and regeneration to neural tissues, supporting cells may provide the necessary metabolic and electrolitic conditions for hair cells mechanical and bioelectrical function. This opens new possibilities for the treatment of apparently "irreversible" destruction of the inner ear.

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Citations

Mar 24, 2010·The Journal of Laryngology and Otology·José Ramón García-BerrocalR Ramírez-Camacho
Jul 13, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fuxin ShiAlbert S B Edge
May 16, 2012·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Celia CasaresJosé Ramón García-Berrocal
Feb 1, 2011·Hearing Research·Zoe F Mann, Matthew W Kelley
Oct 2, 2007·British Journal of Pharmacology·J R García-BerrocalA Trinidad Cabezas
Feb 24, 2015·Experimental & Molecular Medicine·Se-Jin KimRaekil Park
May 17, 2019·The Annals of Otology, Rhinology, and Laryngology·Ivan A LopezAkira Ishiyama
Nov 3, 2021·Physiological Reviews·Carolin Wichmann, Thomas Kuner

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