Central Sensitisation and functioning in patients with chronic low back pain: protocol for a cross-sectional and cohort study.

BMJ Open
Jone Ansuategui EcheitaMichiel F Reneman

Abstract

A relevant subsample of patients with chronic low back pain (CLBP) have manifested augmented central pain processing, central sensitisation (CS). Patients with CLBP have limited functioning and participation. Theoretically, physical functioning in patients with CLBP can plausibly be linked to CS; however, evidence to explain such association is scarce. Moreover, there is no gold standard for CS diagnosis. The objectives of the study are: (1) to analyse the association between instruments assessing reference symptoms and signs attributed to CS; (2) to analyse whether reference symptoms and signs attributed to CS are associated with functioning measurement outcomes; and (3) to analyse whether changes (between baseline and discharge) in reference symptoms and signs attributed to CS are related to changes in each of the functioning measurement outcomes. A cross-sectional and longitudinal observational study is performed with measurements taken at baseline and discharge of an interdisciplinary rehabilitation programme. A sample size of 110 adult patients with CLBP has been calculated for the study. CS measurements are: Central Sensitisation Inventory, quantitative sensory testing and heart rate variability. Functioning measurements ...Continue Reading

References

Jan 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·A W ChanJ A Campbell
Jul 1, 1991·Journal of Neurophysiology·R H LaMotteE F Tsai
Feb 1, 1990·Pain·R C TaitS Krause
Dec 1, 1993·The Journal of Orthopaedic and Sports Physical Therapy·D L HartL N Matheson
Sep 18, 2001·European Journal of Pain : EJP·H FruhstorferO Selbmann
Jul 2, 2002·Occupational Medicine·B C H de ZwartJ C van Duivenbooden
Sep 17, 2002·Journal of Occupational Rehabilitation·Michiel F RenemanLudwig N H Göeken
Jan 14, 2003·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society, UNKNOWN American College of Chest Physicians
Sep 10, 2003·Disability and Rehabilitation·Marguerite SchneidertBedirhan Ustün
Feb 12, 2004·Arthritis and Rheumatism·Thorsten GieseckeDaniel J Clauw
Sep 17, 2004·Journal of Rehabilitation Medicine·Alarcos CiezaRob de Bie
Aug 13, 2005·European Journal of Pain : EJP·Harald BreivikDerek Gallacher
Jan 1, 1996·International Journal of Behavioral Medicine·K I VanderZeeH de Haes
Nov 19, 2005·Medicine and Science in Sports and Exercise·Stewart G TrostRussell R Pate
Sep 6, 2007·American Journal of Pharmaceutical Education·Laurie Kelly McCorry
Jan 1, 2008·The Spine Journal : Official Journal of the North American Spine Society·Simon DagenaisScott Haldeman
Apr 12, 2008·Journal of Occupational Rehabilitation·Remko SoerMichiel F Reneman
Apr 22, 2009·The Journal of Pain : Official Journal of the American Pain Society·Lars Arendt-Nielsen, David Yarnitsky
Aug 21, 2009·The Clinical Journal of Pain·Miroslav-Misha BackonjaMark Wallace
Oct 6, 2009·Archives of Physical Medicine and Rehabilitation·Remko SoerMichiel F Reneman
Nov 10, 2009·Journal of Biomedical Optics·Christina M AmbrosiIgor R Efimov
Apr 20, 2010·Medicine and Science in Sports and Exercise·Scott E CrouterDavid R Bassett
Aug 31, 2010·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Ivan DuqueAlain Duvallet
Sep 22, 2010·Current Rheumatology Reports·Goran Pavlaković, Frank Petzke
Dec 15, 2010·Spine·Ludeke C LambeekWilllem van Mechelen
May 28, 2011·Journal of Science and Medicine in Sport·Jeffer E SasakiPatty S Freedson
Jun 11, 2011·International Archives of Occupational and Environmental Health·P P F M KuijerM H W Frings-Dresen

❮ Previous
Next ❯

Software Mentioned

Power
JAEGER
SPSS
emWave
ActiGraph
GPower
ActiLife6

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
Miranda L van HooffJacques van Limbeek
Scandinavian Journal of Medicine & Science in Sports
P MalliouG Godolias
© 2021 Meta ULC. All rights reserved