Central sensitization predicts greater fatigue independently of musculoskeletal pain

Rheumatology
Katie L Druce, John McBeth

Abstract

To test whether central sensitization was associated with greater fatigue, independently of musculoskeletal pain. 2477 prospective cohort study participants completed a baseline questionnaire comprising the Chalder Fatigue Scale (CFQ), pain, demographics, physical activity, anxiety, depression and medication use. In a clinical assessment of 290 (11.7%) participants, central sensitization was measured by the wind-up ratio test at the hand (WUR-H) and foot (WUR-F). Bioelectric impedance determined proportion body fat. All participants were followed up 12 months later, at which time they completed the CFQ. Linear regression, with inverse probability sampling weights, tested the relationship between WUR at baseline and CFQ at 12 months, adjusted for baseline CFQ, demographics, lifestyle factors, mental health and baseline pain. At baseline, the median interquartile range WUR-H and WUR-F were similar (2.3 (1.5, 4.0) and 2.4 (1.6, 3.9) respectively) and did not differ by sex (difference WUR-H: -0.29, 95% confidence interval -1.28-0.71; WUR-F: -0.57 (-1.50-0.36) or age(WUR-H: -0.53, -1.49-0.43; WUR-F:-0.08, -0.98-0.82). WUR-H scores (β = 0.11, 95% confidence interval: 0.07-0.16) and WUR-F scores (0.13, 0.08-0.17) were positively assoc...Continue Reading

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Citations

Aug 23, 2019·Rheumatology·Katie L Druce, Neil Basu
Nov 5, 2019·Rheumatology·S Mechiel Korte, Rainer H Straub
Jun 22, 2020·Rheumatology International·Mehmet Tuncay DuruözTiraje Tuncer
Nov 30, 2020·Brain, Behavior, and Immunity·Anna-Karin NorlinMaria Engström
Jun 18, 2021·Internal Medicine Journal·Veronica MezhovGeoffrey Littlejohn
Dec 28, 2021·Rheumatology·Onosi Sylvia IfesemenDavid Andrew Walsh
Jan 13, 2022·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Astrid LahousseLaurence Leysen

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