Central sensory-motor crosstalk in the neural gut-brain axis

Autonomic Neuroscience : Basic & Clinical
Coltan G ParkerElizabeth A Davis

Abstract

The neural gut-brain axis consists of viscerosensory and autonomic motor neurons innervating the gastrointestinal (GI) tract. Sensory neurons transmit nutrient-related and non-nutrient-related information to the brain, while motor neurons regulate GI motility and secretion. Previous research provides an incomplete picture of the brain nuclei that are directly connected with the neural gut-brain axis, and no studies have thoroughly assessed sensory-motor overlap in those nuclei. Our goal in this study was to comprehensively characterize the central sensory and motor circuitry associated with the neural gut-brain axis linked to a segment of the small intestine. We injected a retrograde (pseudorabies; PRV) and anterograde (herpes simplex virus 1; HSV) transsynaptic viral tracer into the duodenal wall of adult male rats. Immunohistochemical processing revealed single- and double-labeled cells that were quantified per nucleus. We found that across nearly all brain regions assessed, PRV + HSV immunoreactive neurons comprised the greatest percentage of labeled cells compared with single-labeled PRV or HSV neurons. These results indicate that even though sensory and motor information can be processed by separate neuronal populations, t...Continue Reading

References

Nov 1, 1982·The Journal of Comparative Neurology·M Kalia, J M Sullivan
Mar 19, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Linda Rinaman, Gary Schwartz
Nov 16, 2004·Journal of Virology·Elizabeth E BrittleL W Enquist
May 17, 2005·Virus Research·C Kay SongTimothy J Bartness
Jun 25, 2005·Neuroscience·M CastleA D Loewy
Nov 4, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Cherese N SullivanAyman I Sayegh
May 16, 2008·Expert Opinion on Therapeutic Targets·Alastair V FergusonWillis K Samson
Jan 10, 2012·Peptides·Jizette V HuntAyman I Sayegh
Oct 3, 2012·Proceedings of the National Academy of Sciences of the United States of America·Matthew P TaylorLynn W Enquist
Feb 26, 2013·Viruses·Tal Kramer, Lynn W Enquist
Feb 6, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vitaly RyuTimothy J Bartness
Dec 10, 2015·American Journal of Physiology. Endocrinology and Metabolism·James D O'Hare, Andrea Zsombok
Nov 20, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Nick J SpencerTim Hibberd
Nov 1, 2017·Brain : a Journal of Neurology·Marco Catani
Jun 7, 2018·Nature Communications·Andrea N SuarezScott E Kanoski

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Citations

Jul 3, 2020·Frontiers in Neuroanatomy·Marcos F DosSantosVivaldo Moura-Neto
Feb 16, 2021·Frontiers in Immunology·Edwin Estefan Reza-ZaldívarAlejandro Arturo Canales-Aguirre
Dec 18, 2020·Frontiers in Aging Neuroscience·Ji Yeon ChungJuhyun Song
Jan 9, 2021·The Journal of Experimental Biology·Ayelén Melisa BlancoJosé Luis Soengas

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