Central serotonergic and adrenergic/imidazoline inhibitory mechanisms on sodium and water intake

Brain Research
Lisandra Oliveira MargathoJosé Vanderlei Menani


Recent studies have shown the existence of two important inhibitory mechanisms for the control of NACL and water intake: one mechanism involves serotonin in the lateral parabrachial nucleus (LPBN) and the other depends on alpha(2)-adrenergic/imidazoline receptors probably in the forebrain areas. In the present study we investigated if alpha(2)-adrenergic/imidazoline and serotonergic inhibitory mechanisms interact to control NaCl and water intake. Male Holtzman rats with cannulas implanted simultaneously into the lateral ventricle (LV) and bilaterally into the LPBN were used. The ingestion of 0.3 M NaCl and water was induced by treatment with the diuretic furosemide (10 mg/kg of body weight)+the angiotensin converting enzyme inhibitor captopril (5 mg/kg) injected subcutaneously 1 h before the access of rats to water and 0.3 M NaCl. Intracerebroventricular (i.c.v.) injection of the alpha(2)-adrenergic/imidazoline agonist clonidine (20 nmol/1 microl) almost abolished water (1.6+/-1.2, vs. vehicle: 7.5+/-2.2 ml/2 h) and 0.3 M NaCl intake (0.5+/-0.3, vs. vehicle: 2.2+/-0.8 ml/2 h). Similar effects were produced by bilateral injections of the 5HT(2a/2c) serotonergic agonist 2,5-dimetoxy-4-iodoamphetamine (DOI, 5 microg/0.2 microl eac...Continue Reading


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Apr 20, 1999·Pharmacology, Biochemistry, and Behavior·L A De LucaE W Meyer
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Feb 8, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·José Vanderlei MenaniAlan Kim Johnson

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Dec 2, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lisandra Oliveira MargathoJose Antunes-Rodrigues
Apr 9, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·R L AlmeidaL A De Luca

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