Central sprouting of uninjured small fiber afferents in the adult rat spinal cord following spinal nerve ligation

The European Journal of Neuroscience
Jian HuDavid J Fink

Abstract

Partial nerve injury results in chronic pain that is difficult to treat effectively. To investigate the anatomic basis of this phenomenon we used wheat germ agglutinin-horseradish peroxidase (WGA-HRP) to label the central projections of uninjured small fibers (Adelta and C) in a well-established model of neuropathic pain created by selective spinal nerve ligation in the adult. We found extensive sprouting of uninjured WGA-HRP-labeled afferents into the central termination field in lamina II of dorsal horn normally occupied by L5 afferents whose peripheral axons had been ligated distal to the dorsal root ganglion. The formation of new projections by uninjured fibers into a functionally but not anatomically deafferented field in the adult may play a role in the development of chronic pain.

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Citations

Jan 15, 2008·La Presse médicale·Luis Garcia-Larrea, Michel Magnin
Jun 21, 2011·The Journal of Pain : Official Journal of the American Pain Society·Kumiko TakasuHidenori Suzuki
Jul 24, 2007·Progress in Neurobiology·X NavarroAntoni Valero-Cabré
Jan 20, 2006·The European Journal of Neuroscience·Peter J ShortlandSharon Averill
Jun 12, 2013·The Journal of Comparative Neurology·James H PetersKrzysztof Czaja
Jul 30, 2005·Anesthesiology·Matthias Ringkamp, Richard A Meyer
Nov 1, 2010·Revista Brasileira De Ortopedia·André Luiz de Souza GravaHelton Luiz Aparecido Defino

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