Central Sympathetic Inhibition: a Neglected Approach for Treatment of Cardiac Arrhythmias?

Current Hypertension Reports
Francesca CagnoniMarkus P Schlaich

Abstract

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. Overactivation of the sympathetic nervous system (SNS) plays an important role in the pathogenesis of comorbidities related to AF such as hypertension, congestive heart failure, obesity, insulin resistance, and obstructive sleep apnea. Methods that reduce sympathetic drive, such as centrally acting sympatho-inhibitory agents, have been shown to reduce the incidence of spontaneous or induced atrial arrhythmias, suggesting that neuromodulation may be helpful in controlling AF. Moxonidine acts centrally to reduce activity of the SNS, and clinical trials indicate that this is associated with a decreased AF burden in hypertensive patients with paroxysmal AF and reduced post-ablation recurrence of AF in patients with hypertension who underwent pulmonary vein isolation (PVI). Furthermore, device-based approaches to reduce sympathetic drive, such as renal denervation, have yielded promising results in the prevention and treatment of cardiac arrhythmias. In light of these recent findings, targeting elevated sympathetic drive with either pharmacological or device-based approaches has become a focus of clinical research. Here, we review the data currently available ...Continue Reading

References

Feb 1, 1991·Human Pathology·R VrackoR G Frederickson
Dec 1, 1987·Journal of Clinical Pharmacology·D TrenkV Plänitz
Jan 1, 1986·European Journal of Clinical Pharmacology·V Plänitz
Feb 1, 1986·The American Journal of Cardiology·R D JanesJ A Armour
Feb 1, 1969·The American Journal of Anatomy·J P Ellison, T H Williams
Aug 1, 1982·Circulation·J M IsnerB L Carter
Jan 1, 1994·Journal of Cardiovascular Pharmacology·I Leprán, J G Papp
Apr 1, 1995·Hypertension·G GrassiG Mancia
Feb 1, 1995·The Journal of Thoracic and Cardiovascular Surgery·P L PagéR Cardinal
Jan 1, 1997·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·B N Prichard, B R Graham
Sep 25, 1998·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·M SchachterE Söhlke
Apr 14, 2000·Circulation Research·J M CaoP S Chen
Jun 12, 2002·Circulation·Marco Bettoni, Marc Zimmermann
Nov 13, 2002·Circulation·Guy E AlvarezKevin P Davy
Jul 1, 1959·American Heart Journal·G K MOE, J A ABILDSKOV
Oct 29, 2003·Circulation·Tomasz MazurekYi Shi
Mar 12, 2004·Journal of the American College of Cardiology·Oleg F SharifovLeonid V Rosenshtraukh
Nov 16, 2004·European Heart Journal·Stuart PocockJanet Wittes
May 10, 2005·Stroke; a Journal of Cerebral Circulation·Carmine MariniAntonio Carolei
May 3, 2006·The Journal of Surgical Research·E Victor TselentakisAdam E Saltman
Jun 17, 2006·Diabetes, Obesity & Metabolism·Irina ChazovaEvgeny Shlyakhto
Aug 22, 2006·Journal of Electrocardiology·Benjamin J ScherlagSunny S Po
Sep 27, 2006·Hypertension·Murray EslerElisabeth Lambert
Oct 10, 2006·American Journal of Hypertension·Kazuko MasuoMichael L Tuck
Oct 27, 2006·International Journal of Cardiology·Yuichi SatoSatoshi Saito
Mar 6, 2007·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Peng-Sheng Chen, Alex Y Tan
Jun 15, 2007·Journal of Hypertension·Elisabeth LambertGavin Lambert
Jul 31, 2007·Journal of the American College of Cardiology·Masahiro OgawaPeng-Sheng Chen
Sep 9, 2008·The American Journal of Cardiology·Sanjay SarinJamshid Shirani

❮ Previous
Next ❯

Citations

Feb 8, 2019·Frontiers in Neuroscience·Revathy CarnagarinMarkus P Schlaich

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Related Papers

High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension
Gino SeravalleGuido Grassi
Clinical Research in Cardiology : Official Journal of the German Cardiac Society
Dominik LinzMichael Böhm
EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
Christian UkenaHans-Ruprecht Neuberger
© 2022 Meta ULC. All rights reserved