Central thromboembolism is a possible predictor of right heart dysfunction in normotensive patients with acute pulmonary embolism

Thrombosis Research
T M BerghausM Schwaiblmair

Abstract

Right heart dysfunction is a crucial factor in risk stratification of normotensive patients with pulmonary embolism. Apart from biomarkers, determinants of right heart dysfunction in this group of patients are not yet well established. In order to identify such determinants, we analysed data of 252 patients with acute pulmonary embolism admitted to our hospital in 2008. 69 out of 140 patients showed right heart dysfunction by echocardiography within 24 hours after diagnosis, 71 did not. Right ventricular dysfunction was significantly more frequent in patients with central clots on computed tomography (p=0.004), a history of syncope (p<0.001) and among women on oral contraceptives (p=0.003). In multiple regression analysis, only central thromboembolism (p<0.001) was identified as individual predictor of right ventricular dysfunction. Age, gender, body mass index, idiopathic or recurrent thromboembolism, duration of symptoms, preceding surgery, room air oxygen saturation, carcinoma, hypertension, diabetes, renal disease, congestive left heart failure and concomitant lung disease were equally distributed. In comparison with NT-pro brain natriuretic peptide (PPV 67%, NPV 75%, p=0.782) and troponin I (PPV 76%, NPV 62%, p=0.336), cen...Continue Reading

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Citations

May 26, 2012·Chest·Maria Cristina VedovatiMichele Duranti
Mar 13, 2014·European Heart Journal. Acute Cardiovascular Care·Dmitry DuplyakovElena Surkova
Nov 15, 2015·Vascular Medicine·Akhilesh K SistaSamuel Z Goldhaber
May 23, 2012·Current Opinion in Critical Care·Andrea PenalozaJeffrey Kline

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