PMID: 16505598Mar 1, 2006Paper

Central tolerance and autoimmune diseases

Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology
Takeshi Nitta, Yousuke Takahama

Abstract

Central tolerance is established by the repertoire selection of immature T lymphocytes in the thymus, avoiding autoimmune responses to self-antigens. Differential ligand-TCR interactions that result in positive and negative selection initiate differential intracellular signals that, in turn, lead to the survival-or-death decision of immature thymocytes. TCR signal dysregulation due to the mutation of ZAP-70 or defective apoptosis of autoreactive thymocytes due to the deficiency of pro-apoptotic protein Bim impair tolerance and cause autoimmunity. Thymic repertoire selection also induces the development of CD25(+)CD4(+) regulatory T cells, which play important roles for maintaining peripheral tolerance. Furthermore, the establishment of central tolerance requires the development of thymic medulla that is mediated by the activation of NF-kappaB signaling pathway, promiscuous expression of tissue-specific self-antigens by medullary epithelial cells that is regulated by AIRE, and cortex-to-medulla migration of developing thymocytes that is regulated by CCR7-mediated chemokine signals.

References

Dec 17, 1997·Nature Genetics·K NagamineN Shimizu
Aug 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S ZuklysG A Holländer
Feb 21, 2002·Human Molecular Genetics·Chris RamseyLeena Peltonen
Jul 18, 2002·Immunity·David A HildemanPhilippa Marrack
Sep 24, 2002·Nature Immunology·Jeffrey C RathmellCraig B Thompson
Nov 5, 2002·Annual Review of Immunology·Timothy K StarrKristin A Hogquist
Feb 11, 2003·Nature Immunology·Salah-Eddine Lamhamedi-CherradiYouhai H Chen
Mar 4, 2003·Nature Immunology·Jason D FontenotAlexander Y Rudensky
Mar 4, 2003·Nature Immunology·Roli KhattriFred Ramsdell
Mar 5, 2003·Immunological Reviews·Harald von BoehmerLudger Klein
May 27, 2003·Nature Reviews. Immunology·Ed Palmer
Aug 6, 2003·The Journal of Experimental Medicine·Erika CretneyMark J Smyth
Jan 22, 2004·The Journal of Experimental Medicine·Daisuke UchidaMitsuru Matsumoto
Feb 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fumiko KajiuraMitsuru Matsumoto
Feb 11, 2004·Nature Immunology·Patrick S CostelloRichard Treisman
Mar 5, 2004·Biochimica Et Biophysica Acta·Nathalie M Droin, Douglas R Green
Aug 11, 2004·The Journal of Experimental Medicine·Tomoo UenoYousuke Takahama
Oct 20, 2004·The Journal of Experimental Medicine·Alena M Gallegos, Michael J Bevan
Feb 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Noriyuki KurodaMitsuru Matsumoto
Feb 12, 2005·Science·Taishin AkiyamaJun-ichiro Inoue
Oct 18, 2005·Immunity·April M FischerStephen M Hedrick
Feb 24, 2006·Nature Reviews. Immunology·Yousuke Takahama

❮ Previous
Next ❯

Citations

Jun 1, 2012·BMC Genomics·Gerrit TimmerhausSven Martin Jørgensen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Brain and nerve = Shinkei kenkyū no shinpo
Naoko MatsuiYousuke Takahama
Proceedings of the National Academy of Sciences of the United States of America
Alexander Y W Suen, Troy A Baldwin
Current Opinion in Immunology
Mark S Anderson, Maureen A Su
© 2021 Meta ULC. All rights reserved