Central venous access device insertion and perioperative management of patients with severe haemophilia A: a local experience

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
Adriana FonsecaA Chan

Abstract

Central venous access device (CVAD) insertion is one of the most common procedures performed on paediatric haemophilia patients. There are no clear guidelines outlining the optimal dosing schedule of factor VIII (FVIII) and duration of treatment required to achieve adequate haemostasis during and after surgery. In this article, we describe the experience at McMaster Children's Hospital using FVIII replacement therapy in 15 children with severe haemophilia A during the course of 7 years. This is a retrospective institutional chart review. Patients between 0 and 18 years of age with severe haemophilia A that underwent CVAD insertion at McMaster Children's Hospital in Hamilton, Ontario, from 2004 to 2010, were identified and charts were reviewed. A total of 15 CVAD insertion surgeries were reviewed. The total average preoperative dose of FVIII was 93.5 IU/kg (range: 53.7-145.4 IU/kg). The total average postoperative dose was 818.7 IU/kg (range: 441-1258 IU/kg). The total perioperative dose was 912.2 IU/kg (range: 495.2-1349 IU/kg). The current study attempts to describe the experience at McMaster Children's Hospital for CVAD insertion surgeries, the average factor dose administered has decreased during the years. These results may...Continue Reading

References

Feb 24, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·A SrivastavaA Sudarsanam
Mar 10, 2001·Haemophilia : the Official Journal of the World Federation of Hemophilia·K A High
Jan 9, 2008·Haemophilia : the Official Journal of the World Federation of Hemophilia·C E NeunertG R Buchanan
Oct 30, 2010·Blood Reviews·Leonard A ValentinoMichele Grygotis
Jul 11, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·A SrivastavaUNKNOWN Treatment Guidelines Working Group on Behalf of The World Federation Of Hemophilia

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Citations

Sep 15, 2017·Cardiovascular and Interventional Radiology·Annika R KeulersAndreas H Mahnken
Aug 9, 2018·Haemophilia : the Official Journal of the World Federation of Hemophilia·Helena HägglöfSusanna Ranta
Mar 22, 2021·Haemophilia : the Official Journal of the World Federation of Hemophilia·Koskenvuo MinnaRanta Susanna

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Methods Mentioned

BETA
factor replacement therapy

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