Central venous access devices for paediatric patients with haemophilia: a single-institution experience

Haemophilia : the Official Journal of the World Federation of Hemophilia
R TitapiwatanakunV Rodriguez

Abstract

Use of a central venous access device (CVAD) can facilitate early introduction of home-based infusion of factor concentrate for long-term prophylaxis or immune tolerance therapy in children with bleeding disorders. The aim was to review outcomes associated with use of CVAD. Retrospective review of paediatric patients with bleeding disorders was observed at the Mayo Clinic Comprehensive Hemophilia Center. Thirty-seven CVAD were placed in 18 patients (haemophilia A [n = 15], type 3 von Willebrand disease [n = 2] and haemophilia B [n = 1]). Follow-up was for 45 952 CVAD days, and median time that CVAD remained in place was 1361 days per device. Factor VIII (FVIII) inhibitors were present in 4 of the 15 patients. Ten CVAD-related infections occurred (median, 672 days; range, 72-1941 days), of which six were in one patient with FVIII inhibitors. Overall infection rate was 0.22 (95% confidence interval [CI], 0.10-0.40) per 1000 CVAD days, with 0.11 infections in patients without FVIII inhibitors compared with a pooled incidence of 0.66 (95% CI, 0.44-0.97) reported in the literature. Indications for removal of 27 CVAD were blockage, change to peripheral venous access, catheter displacement, infection, leak in the port septum, short ca...Continue Reading

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Citations

May 21, 2009·Pediatric Surgery International·Manasvi UpadhyayaB R Squire
Jan 28, 2015·Haemophilia : the Official Journal of the World Federation of Hemophilia·A HarrocheC Rothschild
Jun 25, 2015·Haemophilia : the Official Journal of the World Federation of Hemophilia·A R LangleyV Blanchette
Apr 3, 2015·Haemophilia : the Official Journal of the World Federation of Hemophilia·K VepsäläinenP Riikonen
Jun 19, 2010·Haemophilia : the Official Journal of the World Federation of Hemophilia·V Rodriguez, R K Pruthi
Mar 7, 2012·British Journal of Haematology·Rolf C R Ljung, Karin Knobe
Feb 5, 2013·Haemophilia : the Official Journal of the World Federation of Hemophilia·L A ValentinoK Stine
Oct 9, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·J FurmedgeF Newall
Dec 20, 2011·Haemophilia : the Official Journal of the World Federation of Hemophilia·S RantaA Mäkipernaa
Aug 3, 2013·Haemophilia : the Official Journal of the World Federation of Hemophilia·M RajpurkarJ Lusher
Aug 22, 2014·Haemophilia : the Official Journal of the World Federation of Hemophilia·A Torres-OrtuñoJ Nieto-Munuera
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Mar 22, 2021·Haemophilia : the Official Journal of the World Federation of Hemophilia·Koskenvuo MinnaRanta Susanna

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