Centrality of G6PD in COVID-19: The Biochemical Rationale and Clinical Implications

Frontiers in Medicine
Yuliya BuinitskayaSiarhei Kastsiuchenka

Abstract

Introduction: COVID-19 is a novel and devastating disease. Its manifestations vary from asymptomatic to lethal. Moreover, mortality rates differ based on underlying health conditions and ethnicity. We investigated the biochemical rationale behind these observations using machine reasoning by the sci.AI system (https://sci.ai/). Facts were extracted and linked from publications available in nlm.nih.gov and Europe PMC to form the dataset which was validated by medical experts. Results: Based on the analysis of experimental and clinical data, we synthesized detailed biochemical pathways of COVID-19 pathogenesis which were used to explain epidemiological and clinical observations. Clinical manifestations and biomarkers are highlighted to monitor the course of COVID-19 and navigate treatment. As depicted in the Graphical Abstract, SARS-CoV-2 triggers a pro-oxidant (PO) response leading to the production of reactive oxygen species (ROS) as a normal innate defense. However, SARS-CoV-2's unique interference with the antioxidant (AO) system, through suppression of nitric oxide (NO) production in the renin- angiotensin-aldosterone system (RAAS), leads to an excessive inflammatory PO response. The excessive PO response becomes critical in...Continue Reading

References

Jan 1, 1991·Free Radical Research Communications·K Stolze, H Nohl
Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·L L MillerF M Torti
Feb 15, 1985·Archives of Biochemistry and Biophysics·S S Lee, D B McCormick
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·G S HotamisligilB M Spiegelman
Sep 29, 2000·The Journal of Biological Chemistry·Z ZhangR C Stanton
Jul 7, 2001·Clinical Biochemistry·O ErelM Ulukanligil
Aug 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J A LeopoldJ Loscalzo
Mar 13, 2003·Redox Report : Communications in Free Radical Research·Victor VitvitskyRuma Banerjee
Dec 18, 2003·The American Journal of Medicine·James R Sowers
Nov 17, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Luni ChenChen G Wang
Mar 1, 2005·The Journal of Biological Chemistry·Diane E HandyJoseph Loscalzo
Feb 14, 2008·The Journal of Infectious Diseases·Yi-Hsuan WuDaniel Tsun-Yee Chiu
Feb 3, 2009·Free Radical Biology & Medicine·Andreas N KavazisScott K Powers
Feb 24, 2009·Blood Cells, Molecules & Diseases·Ella T NkhomaErnest Beutler
Aug 18, 2009·American Journal of Respiratory Cell and Molecular Biology·Hongqiao Zhang, Henry Jay Forman
Dec 25, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Zhaoyun ZhangRobert C Stanton
Jan 15, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kuichang YuanSuhn Hee Kim
Apr 13, 2010·Biochemical and Biophysical Research Communications·Ming V LiLawrence Chan
Jun 22, 2011·Hypertension·Eric J Belin de ChantemèleDavid W Stepp
Jul 5, 2011·Hormones : International Journal of Endocrinology and Metabolism·Foteini EconomidouAnastasia Kotanidou
Apr 14, 2012·Journal of Amino Acids·Volodymyr I Lushchak
May 19, 2012·BMJ Case Reports·Imran RizviNasar Abdali
Oct 10, 2013·Geriatrics & Gerontology International·Ji-Hung WangBang-Gee Hsu
Jan 5, 2014·Pediatric Hematology and Oncology·Sui-Ling LiaoYi-Hao Weng
Mar 4, 2014·BioMed Research International·Anu RahalKuldeep Dhama
Jun 5, 2014·Journal of Clinical Biochemistry and Nutrition·Yoshimi KobayashiBunnai Ogiso
Jan 1, 2012·World Journal of Emergency Medicine·Mei-Hua Zhang
Oct 7, 2015·Frontiers in Endocrinology·Mary E Moss, Iris Z Jaffe
Dec 30, 2015·Archives of Physiology and Biochemistry·Pawan Kumar MauryaPranjal Chandra
Mar 29, 2016·Chest·Matthew W SemlerUNKNOWN NIH NHLBI ARDS Network

❮ Previous
Next ❯

Citations

Jan 24, 2021·Infectious Diseases and Therapy·Abdulkarim AbdulrahmanManaf AlQahtani
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Christian R GomezIlias Muhammad
Mar 16, 2021·Nucleosides, Nucleotides & Nucleic Acids·Duygu AydemirNuriye Nuray Ulusu
May 20, 2021·Oxidative Medicine and Cellular Longevity·Maria Pina DoreGiovanni Mario Pes

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.