Centrally administered oxytocin elicits exaggerated grooming in oxytocin null mice

Pharmacology, Biochemistry, and Behavior
Janet A AmicoM M McCarthy

Abstract

Experiments were conducted to determine if the chronic absence of the neurotransmitter oxytocin (OT) in null mice resulted in alterations in the responsiveness and abundance of central OT receptors. Self-grooming elicited by intracerebroventricularly administered OT was studied as an indicator of the activation of central OT receptors and autoradiography was used to map the distribution and density of OT receptors in OT null and wild type mice. The intracerebroventricular administration of OT, but not vehicle, artificial cerebrospinal fluid (aCSF), produced a robust increase in grooming behavior in both OT null and wild type animals, P<.001. However, OT-induced grooming was significantly greater in OT null than wild type mice, P<.005. The enhanced grooming was selective to OT as indicated by the finding that grooming to intracerebroventricular arginine vasopressin (AVP) was of the same magnitude in both OT null and wild type mice. OT-induced grooming appears to be mediated through the activation of OT receptors because pretreatment of animals with an OT antagonist, Atosiban, abolished OT-induced grooming, but not AVP-induced grooming. OT receptor distribution and binding in brains of OT null and wild type mice were examined by ...Continue Reading

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Citations

Jul 29, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Luke W AyersJeffrey B Rosen
Oct 20, 2011·American Journal of Physiology. Endocrinology and Metabolism·Gregory J MortonJames E Blevins
Jan 24, 2013·PloS One·Tatiana LevkovichSusan E Erdman
Sep 23, 2009·Experimental Brain Research·India MorrisonHåkan Olausson
Nov 4, 2015·Frontiers in Endocrinology·Alexandra Acevedo-RodriguezRobert J Handa
Mar 10, 2016·Asian-Australasian Journal of Animal Sciences·Siyu Chen, Shusuke Sato
Aug 12, 2016·Developmental Neurobiology·Heather K CaldwellShannah K Witchey
Feb 10, 2017·Early Human Development·Edwa FriedlanderNurit Yirmiya
Jul 21, 2009·Neuropharmacology·Robert H RingSharon Rosenzweig-Lipson
May 25, 2010·Physiology & Behavior·Jan G VeeningHenk P Barendregt
Sep 11, 2017·Neuropharmacology·Nayna M SanatharaOlivier Civelli

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