Centrally patterned rhythmic activity integrated by a peripheral circuit linking multiple oscillators.

Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology
John A Jellies, Daniel Kueh

Abstract

The central pattern generator for heartbeat in the medicinal leech, Hirudo generates rhythmic activity conveyed by heart excitor motor neurons in segments 3-18 to coordinate the bilateral tubular hearts and side vessels. We focus on behavior and the influence of previously un-described peripheral nerve circuitry. Extracellular recordings from the valve junction (VJ) where afferent vessels join the heart tube were combined with optical recording of contractions. Action potential bursts at VJs occurred in advance of heart tube and afferent vessel contractions. Transections of nerves were performed to reduce the output of the central pattern generator reaching the heart tube. Muscle contractions persisted but with a less regular rhythm despite normal central pattern generator rhythmicity. With no connections between the central pattern generator and heart tube, a much slower rhythm became manifest. Heart excitor neuron recordings showed that peripheral activity might contribute to the disruption of centrally entrained contractions. In the model presented, peripheral activity would normally modify the activity actually reaching the muscle. We also propose that the fundamental efferent unit is not a single heart excitor neuron, but ...Continue Reading

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May 25, 2012·The Journal of Experimental Biology·Daniel Kueh, John A Jellies

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Citations

Aug 26, 2014·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·John Jellies
Feb 26, 2013·The Journal of Comparative Neurology·Daniel KuehJohn Jellies
Jun 9, 2015·Cognitive Neurodynamics·Qiang LuXixue Zhang
Aug 7, 2020·Journal of Neurophysiology·Angela WenningRonald L Calabrese
Nov 6, 2015·The Journal of Experimental Biology·Daniel A Wagenaar

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