Centrally regulated blood pressure response to vasoactive peptides is modulated by corticosterone

Journal of Neuroendocrinology
S A B E van AckerE R de Kloet

Abstract

To investigate the role of brain glucocorticoid (GR) and mineralocorticoid receptors (MR) in centrally evoked blood pressure responses, the effects of intracerebroventricular (i.c.v.) administration of angiotensin II and vasopressin were studied in adrenalectomized rats with and without corticosterone or aldosterone replacement. Five groups were examined: (i) Adrenalectomy (ADX); (ii) ADX + a subcutaneously implanted 20-mg corticosterone pellet (low corticosterone); (iii) ADX + 100 mg corticosterone pellet (high corticosterone); (iv) ADX + 6 microg/24 h aldosterone via Alzet minipump (Aldo); and (v) Sham adrenalectomy (Sham). Pressor responses to 150 ng angiotensin II and 50 ng vasopressin i.c.v. were determined in freely moving rats using biotelemetry. The results show that, compared to sham rats, ADX rats showed significantly reduced pressor responses. This reduction of the pressor response to angiotensin II could be reversed and even further enhanced by replacement of the ADX rats with high corticosterone concentrations. In contrast, with aldosterone, a depressor type response was observed. Corticosterone replacement could not restore the pressor response to vasopressin. We conclude that the pressor response to centrally adm...Continue Reading

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Citations

Jun 24, 2005·Infection and Immunity·Mahtab MoayeriEsther M Sternberg
Jan 12, 2005·Physiology & Behavior·UnJa L Hayes, Kathleen C Chambers
Jun 12, 2010·Stress : the International Journal on the Biology of Stress·M OndrejcakovaD Jezova

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