PMID: 9191893May 1, 1997Paper

Centric rings, acentric rings and excess acentric fragments based on a random-walk interphase chromosome model

International Journal of Radiation Biology
H WuT C Yang

Abstract

Excess acentric fragments, consisting of acentric rings and acentric linear fragments, are among the most frequent kinds of chromosome-type aberrations produced by radiation. The frequency of acentric rings cannot be obtained directly by experiment but is estimated here from the ratio of acentric to centric rings, evaluated using a random-walk model for the organization of chromatin during interphase and an assumption that the probability of an exchange formation is proportional to the rate of collision between two DSB. This ratio is calculated to be 2.5 in low-LET irradiated human fibroblasts, significantly greater than the ratio if proximity effects are not considered. The calculated frequency of acentric rings is insufficient to account for all the observed excess acentric fragments. Assuming that the rest of the excess acentric fragments are due to incomplete exchanges, all possible recombinations between two DSB that result in acentric rings and acentric linear fragments have been identified. From the chromosome aberration data, the incompleteness parameter has been estimated. Intra-arm chromosome exchanges, either complete or incomplete, were estimated to account for more than 50% of the excess acentric fragments in human...Continue Reading

References

Apr 1, 1976·Journal of Medical Genetics·J R Savage
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·N E Morton
Jan 1, 1995·Cytogenetics and Cell Genetics·J D TuckerC Shasserre
Jan 1, 1995·International Journal of Radiation Biology·P J Simpson, J R Savage
Aug 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·P HahnfeldtL R Hlatky
Apr 1, 1996·International Journal of Radiation Biology·A M ChenR K Sachs

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Citations

May 10, 2015·Radiation and Environmental Biophysics·M P CaranteF Ballarini
Aug 26, 1998·International Journal of Radiation Biology·R K SachsL R Hlatkys
Oct 20, 2001·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·A OttolenghiM Biaggi
Sep 16, 2003·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·F Ballarini, A Ottolenghi

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