Centrilobular necrosis in autoimmune hepatitis: a histological feature associated with acute clinical presentation

Journal of Clinical Pathology
H HoferE Penner

Abstract

The characteristic histological feature of autoimmune hepatitis (AIH) is interface hepatitis with predominant portal lymphoplasmacytic necroinflammatory infiltration. Centrilobular necrosis (CN), reminiscent of toxic or circulatory liver injury, has been reported in AIH. The aim of this study was to assess the frequency of CN in patients with AIH and its correlation with laboratory and clinical data. Liver biopsies were obtained from 114 patients (90 women, 24 men, mean (SD) age 45.4 (19.4) years) with AIH and were evaluated under code by a single pathologist according to the modified Knodell score. CN was found in 20 (17.5%) patients with virtually unaffected portal areas in four cases. Patients with AIH with CN had a higher total hepatic activity index (median (range) 11 (6 to 15) v 5 (2 to 10)) and presented less frequently with cirrhosis (10% v 38%). Patients with CN had a higher frequency of acute onset (87% v 32%), higher bilirubin (median (range) 12.0 (0.43 to 40.0) v 1.9 (0.36 to 46)) and higher ALT levels (median (range) 25.6 (2.7 to 63.9) v 7.2 (0.7 to 62.6)), than did patients with AIH without centrizonal injury. CN with sparing of the portal areas represents a rare histological pattern in AIH. CN is associated with ...Continue Reading

References

Apr 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N BachF Schaffner
Jan 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A W LohseI R Cohen
Jan 1, 1986·Digestion·R M CrapperI H Frazer
Jun 1, 1995·Journal of Hepatology·K IshakR N MacSween
Jun 1, 1995·The American Journal of Surgical Pathology·L J BurgartA J Czaja
Sep 1, 1994·Journal of Hepatology·R GómezV Maffettone
May 1, 1994·Gut·M R Alison, C E Sarraf
Apr 4, 1996·The New England Journal of Medicine·E L Krawitt
Aug 1, 1997·Gastroenterology·D S PrattM M Kaplan
Jul 27, 1997·Transplantation·A C TsamandasR G Lee
Sep 1, 1995·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·B TurlinB Portmann
Mar 3, 1998·Lancet·N KerkarG Mieli-Vergani
May 9, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A J Demetris
Oct 5, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A J Czaja, H A Carpenter
Jul 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Albert J CzajaUNKNOWN American Association for the Study of Liver Disease
Oct 5, 2002·Transplantation·Steven R MartinFernando Alvarez
Oct 19, 2002·The American Journal of Gastroenterology·Ranvir SinghRobert Perrillo
Jan 24, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Robert P MyersSamuel S Lee
Apr 17, 2004·The American Journal of Surgical Pathology·Joseph MisdrajiFiona M Graeme-Cook

❮ Previous
Next ❯

Citations

Apr 7, 2007·Current Opinion in Gastroenterology·Albert J Czaja
Sep 23, 2008·World Journal of Gastroenterology : WJG·Atsushi TakahashiHiromasa Ohira
May 20, 2009·World Journal of Gastroenterology : WJG·Albert J Czaja, Yusuf Bayraktar
Feb 25, 2010·World Journal of Gastroenterology : WJG·Albert J Czaja
Oct 13, 2012·World Journal of Hepatology·Kazumichi AbeHiromasa Ohira
Sep 8, 2010·Journal of Gastroenterology·Shin YasuiOsamu Yokosuka
Oct 24, 2012·Digestive Diseases and Sciences·Albert J Czaja
Jun 1, 2013·Surgical Pathology Clinics·Cristina D Cole, Romil Saxena
Nov 29, 2015·Journal of Autoimmunity·Qixia WangXiong Ma
May 11, 2010·Gastroenterology·Albert J Czaja, Michael P Manns
May 29, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Y MiyakeK Yamamoto
Feb 13, 2015·Intractable & Rare Diseases Research·Tomohiro TanakaNorihiro Kokudo
Mar 29, 2008·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Masaki IwaiYoshinori Harada
Jun 15, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yasuhiro MiyakeYasushi Shiratori
Dec 5, 2008·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yasuhiro MiyakeKazuhide Yamamoto
Nov 3, 2011·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hiromasa Ohira, Atsushi Takahashi
May 21, 2011·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hiroki Takahashi, Mikio Zeniya
Jan 29, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R Todd StravitzUNKNOWN Acute Liver Failure Study Group
May 27, 2010·Pediatrics International : Official Journal of the Japan Pediatric Society·Akitoshi MurayamaJunji Takeyama
Aug 19, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·John M Vierling
Apr 29, 2015·Journal of Hepatology·Michael P MannsDiego Vergani
May 23, 2015·Digestive Diseases and Sciences·Albert J Czaja
Sep 6, 2015·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver
Jul 8, 2014·Journal of Hepatology·Christina Weiler-Normann, Ansgar W Lohse
Apr 16, 2016·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Giuseppe MaggioreOlivier Bernard
Mar 10, 2015·Frontiers of Medicine·Farhad Sahebjam, John M Vierling
Dec 21, 2010·Journal of Hepatology·Ansgar W Lohse, Giorgina Mieli-Vergani
Apr 19, 2011·Best Practice & Research. Clinical Gastroenterology·Melitta Penz-ÖsterreicherMichael Trauner
Nov 29, 2011·Best Practice & Research. Clinical Gastroenterology·Jawad A IlyasJohn M Vierling
Nov 29, 2011·Best Practice & Research. Clinical Gastroenterology·Albert J Czaja
Feb 25, 2017·Clinical Transplantation·Lauri PuustinenMartti Färkkilä
Feb 22, 2017·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Kazufumi DohmenShinichi Aishima
Jul 1, 2017·Journal of Hepato-biliary-pancreatic Sciences·Keiichi FujiwaraNaoya Kato
Mar 13, 2018·British Journal of Hospital Medicine·Eleni Theocharidou, Michael A Heneghan
Jul 30, 2014·World Journal of Hepatology·Giuseppe MaggioreMarco Sciveres
Apr 22, 2017·Journal of Clinical Pathology·Hiep Nguyen CanhUNKNOWN Intractable Liver and Biliary Diseases Study Group of Japan
Jan 5, 2007·Internal Medicine·Yoshio Tokumoto, Morikazu Onji
Jan 25, 2019·GE Portuguese Journal of Gastroenterology·David N PerdigotoEmanuel Furtado
Mar 23, 2019·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Mussarat N RahimMichael A Heneghan
Oct 12, 2014·Journal of Pediatric Gastroenterology and Nutrition·A Di GiorgioL D'Antiga
Dec 15, 2015·European Journal of Gastroenterology & Hepatology·Yoshio AizawaAkihiko Sakata

❮ Previous
Next ❯

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