Centriole assembly at a glance

Journal of Cell Science
Pierre Gönczy, Georgios N Hatzopoulos

Abstract

The centriole organelle consists of microtubules (MTs) that exhibit a striking 9-fold radial symmetry. Centrioles play fundamental roles across eukaryotes, notably in cell signaling, motility and division. In this Cell Science at a Glance article and accompanying poster, we cover the cellular life cycle of this organelle - from assembly to disappearance - focusing on human centrioles. The journey begins at the end of mitosis when centriole pairs disengage and the newly formed centrioles mature to begin a new duplication cycle. Selection of a single site of procentriole emergence through focusing of polo-like kinase 4 (PLK4) and the resulting assembly of spindle assembly abnormal protein 6 (SAS-6) into a cartwheel element are evoked next. Subsequently, we cover the recruitment of peripheral components that include the pinhead structure, MTs and the MT-connecting A-C linker. The function of centrioles in recruiting pericentriolar material (PCM) and in forming the template of the axoneme are then introduced, followed by a mention of circumstances in which centrioles form de novo or are eliminated.

References

May 1, 1990·The Journal of Cell Biology·R S Kochanski, G G Borisy
Jan 1, 1985·The Journal of Cell Biology·A M TassinM Bornens
Dec 1, 1971·The Journal of Cell Biology·C Fulton, A D Dingle
Dec 1, 1981·The Journal of Cell Biology·R Kuriyama, G G Borisy
Nov 11, 1998·Developmental Biology·G ManandharG Schatten
Jan 17, 2002·Current Opinion in Cell Biology·Michel Bornens
Nov 14, 2002·Molecular Biology of the Cell·Susan K DutcherJohn Stanga
Apr 8, 2004·Developmental Cell·Catherine A KempKevin F O'Connell
Apr 13, 2004·Journal of Cell Science·Marie Delattre, Pierre Gönczy
Sep 24, 2004·Biology of Reproduction·Gaurishankar ManandharPeter Sutovsky
Mar 2, 2005·The Journal of Cell Biology·Sabrina La TerraAlexey Khodjakov
Aug 28, 2007·Cell·Alexander SpektorBrian David Dynlacht
Sep 29, 2007·Current Biology : CB·Madoka HirakiMasafumi Hirono
Nov 6, 2007·Advances in Experimental Medicine and Biology·Michel Bornens, Juliette Azimzadeh
Nov 6, 2007·Current Biology : CB·Maria Ana Gomez-FerreriaDavid J Sharp
Jan 22, 2008·Current Biology : CB·Fei ZhuLaurence Pelletier
Feb 26, 2008·Nature Cell Biology·Jadranka LoncarekAlexey Khodjakov
Dec 6, 2008·Molecular Biology of the Cell·Chad G PearsonMark Winey
Dec 17, 2008·Current Biology : CB·Inês Cunha-FerreiraMónica Bettencourt-Dias
Jan 28, 2009·The Journal of Cell Biology·Gregory C RogersStephen L Rogers
Jun 2, 2009·Current Biology : CB·Thorsten I SchmidtErich A Nigg
Jun 2, 2009·Current Biology : CB·Gregor KohlmaierPierre Gönczy
Jun 9, 2009·Nature Cell Biology·Chieh-Ju C TangTang K Tang
Sep 18, 2009·Developmental Cell·Meng-Fu Bryan TsouPrasad V Jallepalli
Nov 17, 2009·Cell·Erich A Nigg, Jordan W Raff
Dec 25, 2009·Molecular Biology of the Cell·James E SillibourneThierry Grand-Perret
Jan 27, 2010·The Journal of Cell Biology·Andrew J HollandDon W Cleveland
Jul 27, 2010·Current Biology : CB·Jadranka LoncarekAlexey Khodjakov
Nov 4, 2010·Journal of Cell Science·Lillian K Fritz-Laylin, W Zacheus Cande
Nov 10, 2010·The Journal of Cell Biology·Onur CizmeciogluIngrid Hoffmann
Nov 10, 2010·The Journal of Cell Biology·Emily M HatchTim Stearns
Nov 26, 2010·Proceedings of the National Academy of Sciences of the United States of America·Vladimir JoukovDavid M Livingston
Jan 29, 2011·Science·Mark van BreugelBenoît Zuber
Feb 1, 2011·Cell·Daiju KitagawaMichel O Steinmetz
May 18, 2011·The Journal of Cell Biology·Won-Jing WangMeng-Fu Bryan Tsou
Oct 11, 2011·Nature Genetics·Joo-Hee SirFanni Gergely
Oct 12, 2011·The Journal of Cell Biology·Christopher W BrownleeGregory C Rogers
Jan 28, 2012·Science·Michel Bornens
Jun 14, 2012·Nature Reviews. Molecular Cell Biology·Pierre Gönczy
Jul 17, 2012·Science·Paul GuichardPierre Gönczy

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Citations

Jul 13, 2019·Cells·Vladimir Joukov, Arcangela De Nicolo
Feb 29, 2020·Nature Reviews. Molecular Cell Biology·Carsten Janke, Maria M Magiera
Aug 11, 2020·Biology of the Cell·Yaping LiXiumin Yan
Sep 22, 2020·The EMBO Journal·Sergey NazarovPierre Gönczy
May 28, 2020·Cells·Alain DebecTimothy L Megraw
Jan 4, 2020·Journal of Cell Science·Suzanna L Prosser, Laurence Pelletier
Sep 3, 2020·The Journal of Biological Chemistry·Julia M C BuschIoannis Vakonakis
Jan 14, 2021·Open Biology·Cuie Chen, Yukiko M Yamashita
Jan 18, 2021·The Journal of Biological Chemistry·Julia M C BuschIoannis Vakonakis
Nov 22, 2020·Current Opinion in Structural Biology·Ashwani SharmaMichel O Steinmetz
Apr 11, 2021·Seminars in Cell & Developmental Biology·Alejandra Vasquez-Limeta, Jadranka Loncarek
May 8, 2021·Biochemical Society Transactions·Alan Wainman
May 11, 2021·Frontiers in Cell and Developmental Biology·Giulia AscariElfride De Baere
Jun 23, 2021·Nature Communications·Georgios N HatzopoulosPierre Gönczy

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