Centromere glue provides spindle cue

Cell
Renée Deehan, Rebecca Heald

Abstract

During cell division, accurate distribution of the genome by the mitotic spindle requires that sister chromatids remain tethered until the right moment. Studies of an uncharacterized vertebrate protein, Sgo (Salic et al., 2004 [this issue of Cell]), reveal dual roles as a chromosome cohesion factor and a regulator of spindle microtubule dynamics.

References

Nov 25, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Christian H Haering, Kim Nasmyth
Jan 31, 2004·Science·Adele L MarstonAngelika Amon
Jul 23, 2004·Current Biology : CB·Janice Y LeeTerry L Orr-Weaver

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