PMID: 3768847Nov 1, 1986Paper

Centromere spreading and out-of-phase chromatid separation in Burkitt's lymphoma and nasopharyngeal carcinoma

Cancer Genetics and Cytogenetics
S H Zhang

Abstract

Chromosomes with various degrees of centromere spreading and completely separated chromatids, as well as metaphasic chromosomes, were observed simultaneously in the same Burkitt's lymphoma cell. In another study, a pair of prematurely and completely separated chromatids was found in a metaphase of nasopharyngeal carcinoma cell. Based on these and other observations, the possible significance of centromere spreading and out-of-phase sister chromatid separation in the origin of chromosome nondisjunction in tumor cells is suggested and discussed.

References

Jan 1, 1979·American Journal of Medical Genetics·D TomkinsM Roberts
Jun 1, 1984·Cancer Genetics and Cytogenetics·J H GalloJ R Testa
May 15, 1983·International Journal of Cancer. Journal International Du Cancer·Z SizhongZ Yi
Feb 15, 1982·International Journal of Cancer. Journal International Du Cancer·S ZhangG Klein

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Citations

Jun 1, 1988·Human Genetics·S ScappaticciM Fraccaro
Mar 1, 1995·Cancer Genetics and Cytogenetics·D ZhuM Y Li
May 8, 2004·Experimental Gerontology·Biljana Spremo-PotparevicVladan Bajic

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