Centrosomal Abnormalities in Pancreatic Cancer: Molecular Mechanisms and Clinical Implications

Anticancer Research
Daniel AnsariRoland Andersson

Abstract

The centrosome is the main microtubule-organizing center in human cells. It regulates normal cell-cycle progression and cell division. Aberrations in the number, structure and function of centrosomes have been found to drive genomic instability and tumorigenesis. Pancreatic cancer frequently displays centrosomal aberrations. Supernumerary and abnormal centrosomes are observed in the earliest stages of pancreatic tumor development, and the p53 pathway acts as an initial barrier to the proliferation of cells with extra centrosomes. In this review, we summarize recent advances in the understanding of centrosomal aberrations in pancreatic cancer, focusing on regulatory mechanisms and prospects for future anticancer treatment.

Citations

May 30, 2019·Cells·Santina Venuto, Giuseppe Merla
Oct 26, 2018·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Xing Yang, Shaowei Song
Nov 26, 2019·ACS Omega·Praveen Kumar Reddy NagireddySrinivas Kantevari

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