PMID: 8962912Aug 1, 1996Paper

Centrosomal proteins

Biokhimii︠a︡
L A Zinovkina, E S Nadezhdina

Abstract

The review summarizes recent data on structure and function of nearly two dozen centrosomal proteins of the animal cells; centrosome is an organelle that organizes cellular microtubules. Most of these data were obtained by molecular biology techniques including screening of phage expression cDNA libraries with centrosome-specific antibodies, bacterial expression of recombinant proteins recognized by these antibodies, analysis of multiple non-allelic gene of cytoskeletal proteins, etc. new classification of centrosomal proteins is suggested based on their possible centrosomal function comprising proteins of microtubule polymerization templates, structural proteins of pericentriolar material, microtubule severing proteins, microtubule-dependent transport-catalyzing motor proteins, regulatory proteins (specific protein kinases, phosphatases, etc), and centriolar proteins.

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