Centrosome amplification: a suspect in breast cancer and racial disparities

Endocrine-related Cancer
Angela OgdenRitu Aneja

Abstract

The multifaceted involvement of centrosome amplification (CA) in tumorigenesis is coming into focus following years of meticulous experimentation, which have elucidated the powerful abilities of CA to promote cellular invasion, disrupt stem cell division, drive chromosomal instability (CIN) and perturb tissue architecture, activities that can accelerate tumor progression. Integration of the extant in vitro, in vivo and clinical data suggests that in some tissues CA may be a tumor-initiating event, in others a consequential 'hit' in multistep tumorigenesis, and in some others, non-tumorigenic. However, in vivo data are limited and primarily focus on PLK4 (which has CA-independent mechanisms by which it promotes aggressive cellular phenotypes). In vitro breast cancer models suggest that CA can promote tumorigenesis in breast cancer cells in the setting of p53 loss or mutation, which can both trigger CA and promote cellular tolerance to its tendency to slow proliferation and induce aneuploidy. It is thus our perspective that CA is likely an early hit in multistep breast tumorigenesis that may sometimes be lost to preserve aggressive karyotypes acquired through centrosome clustering-mediated CIN, both numerical and structural. We a...Continue Reading

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Citations

Dec 1, 2017·Journal of Cell Communication and Signaling·Vijayalaxmi GuptaSushanta K Banerjee
Aug 16, 2017·Endocrine-related Cancer·Karen Crasta, Ritu Aneja
Mar 12, 2019·PLoS Computational Biology·Bernardo P de AlmeidaNuno L Barbosa-Morais
Jul 28, 2020·Virchows Archiv : an International Journal of Pathology·Shin-Ichi MurataFumiyoshi Kojima
Nov 11, 2020·Biochimica Et Biophysica Acta. Reviews on Cancer·Christopher A RaabKlaus Strebhardt
Mar 6, 2021·Cell & Bioscience·Qi WuSi Sun
Oct 5, 2021·Endocrinology·Katrina M PiemonteRuth A Keri

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