CEP55 Positively Affects Tumorigenesis of Esophageal Squamous Cell Carcinoma and Is Correlated with Poor Prognosis.

Journal of Oncology
Shu-Mei YanRong-Zhen Luo

Abstract

Centrosomal protein 55 (CEP55) is a centrosome- and midbody-associated protein that is overexpressed in several cancers. However, the underlying molecular mechanism of CEP55-mediated progression and metastasis of esophageal squamous cell carcinoma (ESCC) is not clear. In the current study, we detected CEP55 mRNA by qRT-PCR while protein expression was detected by western blot analysis and immunohistochemistry (IHC). In addition, we knocked down CEP55 and investigated the ability of CEP55 to affect colony formation and migration. Here, we report that CEP55 mRNA and protein expression was significantly increased in ESCC. IHC staining showed that CEP55 expression correlated with TNM stage (p=0.046) and lymph node metastases (p=0.024). According to overall survival (OS) and disease-free survival (DFS), patients whose tumors expressed a higher level of CEP55 had a poorer prognosis than those with low expression level of CEP55. A multivariate analysis revealed that CEP55 expression was an independent prognostic indicator for patients with ESCC. Knockdown of CEP55 decreased the colony formation ability and migration of ESCC cells and also reduced the phosphorylation of Src, FAK, and ERK. Therefore, our study implied that CEP55 may be ...Continue Reading

References

Jul 14, 1998·Nature Medicine·J KononenO P Kallioniemi
Nov 3, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·K NemotoY Hosoi
Jul 30, 2003·Cancer Metastasis Reviews·Justin M Summy, Gary E Gallick
Jul 13, 2004·Biochimica Et Biophysica Acta·Michele A WozniakPatricia J Keely
Aug 22, 2006·Current Opinion in Cell Biology·Satyajit K Mitra, David D Schlaepfer
Jan 24, 2008·Japanese Journal of Clinical Oncology·Yoshiyuki ShioyamaHiroshi Honda
Jul 18, 2009·Journal of Immunotherapy·Satoko InodaNoriyuki Sato
Apr 7, 2010·Annals of Surgical Oncology·Thomas W RiceValerie W Rusch
Sep 28, 2010·Chinese Journal of Cancer·Steven H Lin, Joe Y Chang
Oct 19, 2010·Experimental and Molecular Pathology·Satoko InodaNoriyuki Sato
Jun 1, 2012·The New England Journal of Medicine·P van HagenUNKNOWN CROSS Group
Jan 10, 2013·Current Cancer Drug Targets·Mitchell Cheung, Joseph R Testa
Feb 5, 2013·Lancet·Arjun PennathurJames D Luketich
Jan 7, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jinqiu TaoZekuan Xu
Feb 19, 2015·Journal of the National Comprehensive Cancer Network : JNCCN·Jaffer A AjaniUNKNOWN National comprehensive cancer network
Apr 29, 2015·Oncogene·J JefferyK K Khanna
Jul 18, 2015·World Journal of Gastroenterology : WJG·María José Domper ArnalÁngel Lanas Arbeloa
Jul 28, 2015·Journal of Pharmaceutical Sciences and Pharmacology·M C SekarA Wells

❮ Previous
Next ❯

Software Mentioned

SPSS
MedCalc

Related Concepts

Related Feeds

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.