Cephalosporin-aminoglycoside synergistic nephrotoxicity: fact or fiction?

Drug Intelligence & Clinical Pharmacy
J C MannionN G Popovich

Abstract

A review of synergistic nephrotoxicity associated with the concomitant administration of aminoglycoside and cephalosporin antibiotics is presented. A combination of these antibiotics is frequently administered in clinical practice as initial therapy in the treatment of gram-negative bacillary infection. The nephrotoxicity associated with cephalosporin/aminoglycoside administration in humans has been characterized as an acute tubular necrosis. Attempts to investigate this type of toxicity in animals using the rat as the model have revealed that the rat kidney is not affected by the aminoglycoside/cephalosporin combination in the same manner as the human kidney. The results from studies using the rat were not predictive of the nephrotoxicity encountered in humans, and cephalosporins actually appear to protect the rat from aminoglycoside-induced renal damage. The mechanism of the protective effect in rats and the toxic effects in man remain unknown. A species differentiation clearly exists between man and rats with respect to the nephrotoxic effects of aminoglycoside/cephalosporin combinations. The weight of present evidence indicates that, in man, an aminoglycoside/cephalosporin combination is synergistically nephrotoxic.

References

May 1, 1978·The Journal of Antimicrobial Chemotherapy·A WheltonW G Walker
Sep 1, 1977·Clinical Pharmacology and Therapeutics·J J Schentag, W J Jusko
Nov 1, 1977·Antimicrobial Agents and Chemotherapy·D M HahnP H Wiernik
Nov 1, 1978·Annals of Internal Medicine·R Quintiliani, C H Nightingale
May 1, 1979·Clinical Pharmacokinetics·J C Pechere, R Dugal
Mar 24, 1977·The New England Journal of Medicine·G B Appel, H C Neu
Jan 1, 1978·Chemotherapy·E T AndersonW L Hewitt
Jan 1, 1979·Antimicrobial Agents and Chemotherapy·R BlochD R Maxwell
Jan 1, 1979·Nephron·B L Thomas, G C Faith
May 1, 1979·Antimicrobial Agents and Chemotherapy·L I RankinF C Luft
Oct 1, 1979·Kidney International·E Pastoriza-MunozG J Kaloyanides
Jan 1, 1978·Antimicrobial Agents and Chemotherapy·D N GilbertG Porter
Mar 1, 1978·The Journal of Antimicrobial Chemotherapy·F P Marsh
May 1, 1978·The Journal of Infectious Diseases·J S WoldD M Morton
May 1, 1978·The Journal of Infectious Diseases·M Barza
May 1, 1978·The Journal of Antimicrobial Chemotherapy·J J SchentagT J Cumbo
May 1, 1978·The Journal of Antimicrobial Chemotherapy·G KahlmeterC Kamme
May 1, 1978·The Journal of Antimicrobial Chemotherapy·M BarzaT Murray
May 1, 1978·The Journal of Antimicrobial Chemotherapy·N E ReinerW L Thompson
Jun 1, 1978·Journal of Pharmacokinetics and Biopharmaceutics·W A ColburnM Gibaldi
Aug 1, 1978·Antimicrobial Agents and Chemotherapy·P J Chiu, J F Long
Sep 1, 1978·Antimicrobial Agents and Chemotherapy·F C LuftM N Yum
Jan 1, 1977·Acta Medica Scandinavica·M M Hansen, K Kaaber
Oct 1, 1977·Antimicrobial Agents and Chemotherapy·J S WoldN V Owen
Oct 1, 1977·Antimicrobial Agents and Chemotherapy·R L BowmanG J Kaloyanides
Jun 1, 1976·Antimicrobial Agents and Chemotherapy·C Q EdwardsP S Lietman
May 1, 1976·Antimicrobial Agents and Chemotherapy·F C LuftS A Kleit
Jul 1, 1976·Antimicrobial Agents and Chemotherapy·W L FanningH Jick
Nov 1, 1976·Antimicrobial Agents and Chemotherapy·F C LuftS A Kleit
Aug 1, 1975·The Journal of Infectious Diseases·B M Tune
Jul 1, 1975·Antimicrobial Agents and Chemotherapy·J G DahlgrenW L Hewitt
Aug 1, 1975·Antimicrobial Agents and Chemotherapy·W O HarrisonM Turck
Jan 1, 1975·The Journal of Antimicrobial Chemotherapy·R D Foord
Jan 1, 1976·Antimicrobial Agents and Chemotherapy·P DellingerL Weinstein
Apr 1, 1976·Antimicrobial Agents and Chemotherapy·P DellingerL Weinstein
Jul 1, 1973·The American Journal of the Medical Sciences·J KlasterskyL Vandenborre
Apr 1, 1969·The Journal of Infectious Diseases·F G FalcoG M Arcieri

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Citations

Jan 5, 2002·Journal of Chemotherapy·V Fanos, L Cataldi
Nov 18, 2005·Current Opinion in Critical Care·Miet SchetzThomas Golper

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