Ceramic Biocomposites as Biodegradable Antibiotic Carriers in the Treatment of Bone Infections

Journal of Bone and Joint Infection
Jamie FergusonM A McNally

Abstract

Local release of antibiotic has advantages in the treatment of chronic osteomyelitis and infected fractures. The adequacy of surgical debridement is still key to successful clearance of infection but local antibiotic carriers seem to afford greater success rates by targeting the residual organisms present after debridement and delivering much higher local antibiotic concentrations compared with systemic antibiotics alone. Biodegradable ceramic carriers can be used to fill osseous defects, which reduces the dead space and provides the potential for subsequent repair of the osseous defect as they dissolve away. A dissolving ceramic antibiotic carrier also raises the possibility of single stage surgery with definitive closure and avoids the need for subsequent surgery for spacer removal. In this article we provide an overview of the properties of various biodegradable ceramics, including calcium sulphate, the calcium orthophosphate ceramics, calcium phosphate cement and polyphasic carriers. We summarise the antibiotic elution properties as investigated in previous animal studies as well as the clinical outcomes from clinical research investigating their use in the surgical management of chronic osteomyelitis. Calcium sulphate pell...Continue Reading

References

Jul 1, 1980·Archives of Otolaryngology·A S Coetzee
Jan 1, 1993·The Journal of Bone and Joint Surgery. British Volume·F KorkusuzK Ono
Sep 1, 1993·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·C N CornellB D Brause
Aug 1, 1996·Clinical Orthopaedics and Related Research·R W KendallJ H Ngui-Yen
Aug 1, 1996·Clinical Orthopaedics and Related Research·E D ArringtonN A Davino
Jan 1, 1996·Journal of Biomedical Materials Research·C HamanishiT Kitahashi
Jan 27, 2000·The Journal of Trauma·T J BlokhuisH J Haarman
Jul 6, 2000·The Orthopedic Clinics of North America·S N KhanJ M Lane
Jan 12, 2001·Clinical Orthopaedics and Related Research·C M KellyP T Kim
Jun 21, 2001·ANZ Journal of Surgery·W R MooreG I Bain
Jul 21, 2001·Lancet·P S Stewart, J W Costerton
Aug 2, 2002·Clinical Orthopaedics and Related Research·Mark E ShirtliffJon T Mader
Aug 10, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Carl L NelsonKeith M Olsen
Oct 29, 2002·Journal of Orthopaedic Surgery·Steven Gitelis, Gregory T Brebach
Jun 5, 2003·Clinical Orthopaedics and Related Research·Joseph BorrelliWilliam M Ricci
Sep 11, 2003·Clinical Orthopaedics and Related Research·George CiernyJohan J Penninck
Aug 2, 2005·Clinical Orthopaedics and Related Research·Thomas M TurnerSteven Gitelis
Aug 17, 2005·Injury·Rozalia DimitriouPeter V Giannoudis
Dec 7, 2005·Clinical Orthopaedics and Related Research·Darryl B ThomasJoseph C Wenke
Jun 3, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·M P GinebraJ A Planell
Jun 23, 2006·Drugs·Andrej Trampuz, Werner Zimmerli
Aug 1, 2006·The Journal of Bone and Joint Surgery. British Volume·J C WenkeD E Brooks
Mar 30, 2007·International Orthopaedics·M ColangeliS Giannini
Jun 2, 2007·The Journal of Bone and Joint Surgery. British Volume·C DelloyeO Barbier
Aug 19, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P V GiannoudisT A Einhorn
Dec 18, 2007·FEMS Immunology and Medical Microbiology·Rebecca A BradyMark E Shirtliff
Apr 24, 2008·Clinical Orthopaedics and Related Research·Nathan D WebbWarren O Haggard
Apr 29, 2008·Biomaterials·David F Williams
Dec 17, 2008·Current Stem Cell Research & Therapy·Mirjam FröhlichGordana Vunjak-Novakovic
Jun 24, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zongping XieJianqiang Wang
Aug 25, 2009·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Brandon M Scharer, Shawn M Sanicola
Dec 9, 2009·Biomaterials·Sergey V Dorozhkin
Jun 25, 2010·European Cells & Materials·M Bohner
Feb 15, 2011·Archives of Orthopaedic and Trauma Surgery·Yulu WangZhijun Pan
May 14, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Christopher R RathboneJoseph C Wenke
Aug 23, 2011·Acta Biomaterialia·Faleh TamimiJake Barralet
Sep 22, 2011·European Archives of Psychiatry and Clinical Neuroscience·Knut Schnell, Sabine C Herpertz
Sep 29, 2011·Acta Biomaterialia·Sergey V Dorozhkin

❮ Previous
Next ❯

Citations

Apr 17, 2019·Journal of Biomaterials Applications·Rema A OliverWilliam R Walsh
Oct 9, 2019·Journal of the American Academy of Orthopaedic Surgeons. Global Research & Reviews·Ulrik Kähler OlesenJohn E Herzenberg
Feb 27, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Brian AllenKen Gall
May 23, 2017·Journal of Bone and Joint Infection·Antonia F Chen, Heinz Winkler
Aug 26, 2020·Journal of Materials Science. Materials in Medicine·Rema A OliverWilliam R Walsh
Mar 15, 2018·Current Osteoporosis Reports·Claudia SchlundtKatharina Schmidt-Bleek
Aug 30, 2019·Journal of Orthopaedic Trauma·Willem-Jan MetsemakersUNKNOWN Fracture-Related Infection (FRI) consensus group
Apr 17, 2019·Materials·Elisabeth BeuttelBritt Wildemann
Mar 20, 2021·Journal of Clinical Orthopaedics and Trauma·Robert G FrykbergVenu Kavarthapu
May 1, 2021·International Journal of Molecular Sciences·André BuschAndrea Sowislok
Jun 16, 2021·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Louise Kruse Jensen
Aug 5, 2021·Journal of Bone and Joint Infection·Henry T ShuBabar Shafiq
Jul 23, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Markus RuppMaximilian Kerschbaum
Jan 5, 2021·Journal of Orthopaedic Trauma·Jessica C RiveraJanet D Conway
Jul 30, 2021·Expert Opinion on Pharmacotherapy·Raju AhluwaliaNicola Maffulli
Sep 17, 2020·Current Drug Delivery·Marina GallarateSimona Sapino

❮ Previous
Next ❯

Methods Mentioned

BETA
total hip arthroplasty 69

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.