Ceramidastin, a novel bacterial ceramidase inhibitor, produced by Penicillium sp. Mer-f17067

The Journal of Antibiotics
Hiroyuki InoueDaishiro Ikeda

Abstract

Decrease of ceramide in the skin is one of the aggravating factors of atopic dermatitis. The skin is often infected by ceramidase-producing bacteria, such as Pseudomonas aeruginosa. The bacterial ceramidase then degrades ceramide in the skin. To develop anti-atopic dermatitis drugs, we searched for ceramidase inhibitors, which led to the discovery of ceramidastin, a novel inhibitor of bacterial ceramidase, from the culture broth of Penicillium sp. Mer-f17067. Ceramidastin inhibited the bacterial ceramidase with an IC(50) value of 6.25 microg ml(-1). Here we describe the isolation, physicochemical properties, structure determination and biological activity of ceramidastin.

References

May 17, 1978·European Journal of Clinical Pharmacology·P E LucchelliJ Zattoni
Jan 1, 1991·Advances in Lipid Research·P M Elias, G K Menon
Nov 4, 1970·Journal of the American Chemical Society·G BüchiS Singh
May 28, 1994·Lancet·J D BosJ H Smitt
May 24, 1996·The Journal of Biological Chemistry·A BielawskaY A Hannun
Oct 4, 1996·The Journal of Biological Chemistry·M E VenableL M Obeid
Apr 16, 1998·Japanese Journal of Pharmacology·J HiroiK Esaki
Jun 11, 1998·The Journal of Biological Chemistry·N OkinoM Ito
Jan 5, 1999·Clinical and Diagnostic Laboratory Immunology·Y OhnishiS Imayama
Feb 13, 2001·The British Journal of Dermatology·A AioiH Matsuda

❮ Previous
Next ❯

Citations

Jul 22, 2010·The Journal of Antibiotics·Hiroyuki InoueDaishiro Ikeda
Mar 3, 2010·Progress in Lipid Research·Patricia GangoitiAntonio Gómez-Muñoz
Aug 15, 2014·Natural Product Reports·Anja Schueffler, Timm Anke
Nov 25, 2011·Molecular and Cellular Biochemistry·Xing LiuGuang-Hui Yi
Dec 29, 2020·Current Cancer Drug Targets·Helen Shiphrah VethakanrajAshok Kumar Sekar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.