Ceramide Accumulation Is Associated with Declining Verbal Memory in Coronary Artery Disease Patients: An Observational Study

Journal of Alzheimer's Disease : JAD
Parco ChanKrista L Lanctôt

Abstract

Biomarkers in cognitively vulnerable populations, like those with coronary artery disease (CAD), may inform earlier intervention in vascular neurodegeneration. Circulating ceramide C18:0 (CerC18:0) is associated with changes in verbal memory in early neurodegeneration and CAD progression. To investigate whether plasma CerC18:0 accumulation is associated with longitudinal declines in verbal memory performance in CAD. In addition to total CerC18:0, we assessed its relative abundance to its precursors as ratios: CerC18:0 to monohexosylceramide C18:0 (MHxCer18:0), CerC18:0 to sphingomyelin C18:0 (SM18:0), and CerC18:0 to sphingosine-1-phosphate (S1P). Verbal memory was assessed using the California Verbal Learning Test 2nd Ed. Using mixed models in 60 CAD participants, we evaluated associations between baseline CerC18:0 ratios and changes in verbal memory performance, adjusting for age, body mass index, and education. Given that cognitive decline is more rapid following onset of deficits, these associations were compared between those with possible mild vascular neurocognitive disorder (MVND). Increased baseline CerC18:0 concentrations correlated with worse verbal memory performance over time (b[SE] = - 0.91[0.30], p = 0.003). Incr...Continue Reading

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Citations

Sep 17, 2020·Pharmacological Reports : PR·Liubov S KalinichenkoChristian P Müller
Jun 17, 2020·Journal of Alzheimer's Disease : JAD·Cameron Isaacs-TrepanierKrista L Lanctôt
Oct 13, 2020·Cerebral Cortex·Liubov S KalinichenkoChristian P Müller

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