Ceramide content is higher in type I compared to type II fibers in obesity and type 2 diabetes mellitus

Acta Diabetologica
Ditte KristensenJ W Helge

Abstract

This study investigated fiber-type-specific muscle ceramide content in obese subjects and type 2 diabetes patients. Two substudies, one which compared type 2 diabetes patients to both lean- and obese BMI-matched subjects and the other study which compared lean body-matched post-obese, obese, and control subjects, were performed. A fasting blood sample was obtained and plasma insulin and glucose determined. A muscle biopsy was obtained from deltoideus and vastus lateralis, and fiber-type ceramide content was determined by fluorescence immunohistochemistry. Insulin sensitivity estimated by Quicki index was higher in lean compared to type 2 diabetes patients and obese controls. Also in control and post-obese subjects, a higher insulin sensitivity was observed compared to obese subjects. Ceramide content was consistently higher in type I than in type II muscle fibers and higher in deltoideus than vastus lateralis across all groups. No significant differences between groups were observed in ceramide content in either of the two substudies. In human skeletal muscle, ceramide content was higher in type I than in type II fibers in patients with type 2 diabetes and in obese subjects, but overall ceramide muscle fiber content was not dif...Continue Reading

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Citations

Nov 26, 2013·Mechanisms of Ageing and Development·Kavita S JadhavDavid L Williamson
Oct 21, 2016·Obesity Research & Clinical Practice·Sintip PattanakuharSiriporn C Chattipakorn
Sep 27, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ditte SøgaardJørn Wulff Helge
Nov 12, 2013·The Journal of Biological Chemistry·Jose A ChavezScott A Summers
Nov 14, 2017·Current Pharmacology Reports·Eric K KwongHuiping Zhou

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