Ceramide counteracts the effects of ghrelin on the metabolic control of food intake in rainbow trout

The Journal of Experimental Biology
Cristina VelascoJosé L Soengas

Abstract

In mammals, ceramides are involved in the modulation of the orexigenic effects of ghrelin (GHRL). We previously demonstrated in rainbow trout that intracerebroventricular (ICV) treatment with ceramide (2.5 µg/100 g fish) resulted in an anorexigenic response, i.e. a response opposed to that described in mammals, where ceramide treatment is orexigenic. Therefore, we hypothesized that the putative interaction between GHRL and ceramide must be different in fish. Accordingly, in a first experiment, we observed that ceramide levels in the hypothalamus of rainbow trout did not change after ICV treatment with GHRL. In a second experiment, we assessed whether the effects of GHRL treatment on the regulation of food intake in rainbow trout changed in the presence of ceramide. Thus, we injected ICV GHRL and ceramide alone or in combination to evaluate in hypothalamus and hindbrain changes in parameters related to the metabolic control of food intake. The presence of ceramide generally counteracted the effects elicited by GHRL on fatty acid-sensing systems, the capacity of integrative sensors (AMPK, mTOR and SIRT-1), proteins involved in cellular signalling pathways (Akt and FoxO1) and neuropeptides involved in the regulation of food intake...Continue Reading

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Citations

Sep 28, 2017·Journal of Molecular Endocrinology·Cristina VelascoJosé L Soengas
Jun 28, 2019·Frontiers in Endocrinology·Francisco Javier Sánchez-VázquezJesús M Míguez
Jul 16, 2020·The Journal of Experimental Biology·Cristina VelascoJosé L Soengas
Mar 16, 2021·Frontiers in Neuroscience·José L Soengas

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