Ceramide lipid-based nanosuspension for enhanced delivery of docetaxel with synergistic antitumor efficiency.

Drug Delivery
Tianqi WangNa Zhang

Abstract

Ceramide (CE), a bioactive lipid with tumor suppression, has been widely used as a drug carrier and enhancer for cancer therapy. CE-based combination therapy was prone to be attractive in cancer therapy. In our previous study, the combination of CE and docetaxel (DTX) was proved to be an effective strategy for cancer therapy. To further improve the antitumor efficiency of DTX, the CE lipid-based nanosuspensions (LNS) was prepared for the delivery of DTX to exhibit synergistic therapeutic effect. The enhanced delivery and synergistic therapeutic effect of DTX-loaded CE-LNS (CE + DTX-LNS) were evaluated. CE + DTX-LNS exhibited spherical or ellipsoidal shape, uniform particle size distribution (108.1 ± 3.8 nm), sustained release characteristics and good stability in vitro. Notably, CE + DTX-LNS could effectively co-localize CE and DTX into same tumor cell and subsequently play synergistic cell damage effect compared with CE-LNS + DTX-LNS (p < 0.05). The in vivo fluorescence imaging results showed that CE + DTX-LNS could effectively prolong the in vivo circulation time and enhance the accumulation in tumor sites. Moreover, the antitumor efficacy of CE + DTX-LNS observed in B16 murine melanoma model was 93.94 ± 2.77%, significantly ...Continue Reading

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Citations

Feb 19, 2019·Expert Opinion on Drug Delivery·Enhui ZhangPengcheng Li
Nov 21, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Shuang LiangNa Zhang
Aug 15, 2019·AAPS PharmSciTech·Hamad AlrbyawiR Jayachandra Babu
Jul 3, 2020·Nanomedicine : Nanotechnology, Biology, and Medicine·Ruijuan WangYerong Xiong
Mar 3, 2020·Advanced Drug Delivery Reviews·Livia Neves Borgheti-CardosoMaria Vitória Lopes Badra Bentley

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