Ceramides and glycosphingolipids in maturation process: leukemic cells as an experimental model

Blood Cells, Molecules & Diseases
G Smoleńska-SymJ Kościelak

Abstract

Leukemic cells were used as experimental material to demonstrate changes in the content of GSLs during the development and maturation of neutrophils. The most abundant cellular GSL is LacCer. An elevation in the LacCer level occurs twice during the maturation process: initially, on formation of azurophil granules, and subsequently, (a more significant rise) on formation of specific granules. The formation of the latter is accompanied by an increase in the level of GalGalCer. During the maturation of myeloblasts, there is a simultaneous growth in the content of LacCer and GM3 as well as that of their common precursors, that is, free ceramides. Like other tumor cells, GM3 rich myeloblasts in the peripheral blood from patients with AML are characterized by shedding of gangliosides. The quantitative Cer/GlcCer ratio in these cells seems to be advantageous for the efficacy of chemotherapy in the induction of apoptosis. Myelo- and metamyelocytes achieve the highest level of GSLs. Their entry into the full maturity stage is accompanied by a decrease in the level of GSLs. Patterns of GSLs expression change greatly during development and maturation. However, with respect to the composition and content of GSLs, there are no significant d...Continue Reading

References

Sep 3, 1982·Molecular and Cellular Biochemistry·B A MacherM A Westrick
Apr 1, 1993·European Journal of Haematology·N BorregaardH Sengeløv
Aug 9, 1996·The Journal of Biological Chemistry·Y LavieM C Cabot
Feb 20, 1998·Journal of Leukocyte Biology·B Kniep, K M Skubitz
Oct 10, 1998·Biochimica Et Biophysica Acta·Y KongS Ladisch
Nov 26, 1998·The Journal of Biological Chemistry·Y LavieM Liscovitch
Aug 4, 1999·Proceedings of the National Academy of Sciences of the United States of America·T YamashitaR L Proia
Oct 16, 1999·The Journal of Biological Chemistry·R L ThomasA A Amoscato
Apr 20, 2000·The Journal of Biological Chemistry·D A Brown, E London
Nov 21, 2000·Trends in Biochemical Sciences·M Liscovitch, Y Lavie
Feb 24, 2001·Glycoconjugate Journal·K Kasahara, Y Sanai
Mar 22, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Y Y LiuM C Cabot
May 15, 2001·Biochemical and Biophysical Research Communications·D KalkaM Cantz
Jun 20, 2001·Nature Reviews. Molecular Cell Biology·K Simons, D Toomre
Jun 23, 2001·The Journal of Membrane Biology·H SietsmaJ W Kok
Sep 12, 2001·Advanced Drug Delivery Reviews·Y LavieM Liscovitch
Jan 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Sen-itiroh Hakomori Si
Aug 1, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yoichiro KakugawaTaeko Miyagi
Aug 1, 2002·Proceedings of the National Academy of Sciences of the United States of America·Senitiroh Hakomori
Dec 17, 2002·Current Opinion in Hematology·Senitiroh Hakomori
Dec 18, 2002·The Journal of Biological Chemistry·Alessandro PrinettiSandro Sonnino
Apr 23, 2003·Experimental Cell Research·Olivier GasserJürg A Schifferli

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