PMID: 1203250Dec 17, 1975Paper

Ceramides of human normal and cataractous lens

Biochimica Et Biophysica Acta
R V Tao, E Cotlier

Abstract

Ceramides were quantitatively isolated from human normal and cataractous lens by solvent extraction, silicic acid chromatography, thin-layer chromatography, and gas-liquid chromatography. Only two species of ceramides with normal fatty acids were detected. In the mature cataracts, there was an increase in palmitate and nervonate at the expense of the other fatty acids. Due to the increase of 24 : 1, the ratio of 24 : 1/24 : 0 increased significantly from normals to cataracts. Sphinganine was the major long-chain base, but 4-sphingenine was also present. The total amount of ceramides in the immature and mature cataracts was 1.8 and 3.0 times higher than the normals of the same age group. Such an increase does not seem to be the result of an age-dependent process.

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Citations

Sep 7, 2011·Age·Jessica R HughesTodd W Mitchell
Mar 5, 2004·Chemistry and Physics of Lipids·M Cecilia Yappert, Douglas Borchman
Feb 9, 2002·The Journal of Nutritional Biochemistry·W J. BettgerC B. Blackadar
Jul 6, 2000·Experimental Eye Research·M H Garner
Nov 1, 1984·Current Eye Research·P S Zelenka
Jan 1, 1982·Current Eye Research·M M GoodenD A Rintoul
Mar 30, 2001·The Journal of Biological Chemistry·R F JacobR P Mason
Jul 1, 1984·Current Eye Research·S ZigmanS Girsch
Apr 1, 1990·Current Eye Research·B Y YueJ Sugar
Aug 25, 1978·Biochimica Et Biophysica Acta·E CotlierB Toftness
Aug 29, 1983·Biochimica Et Biophysica Acta·R V TaoE Cotlier
Jul 1, 1983·Experimental Eye Research·J DillonA Spector
Jan 12, 2005·Experimental Eye Research·Douglas BorchmanMuhammad Afzal

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